the Signaling Pathways Project (SPP), that enhances the FAIR status of public cell signaling ‘omics datasets along three dimensions. Firstly, SPP encompasses datasets involving genetic
Integrated mining of public transcriptomic and ChIP-Seq datasets has the potential to illuminate facets of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates stable community ...
Applications, Representation, and Management of Signaling Pathway Information: Introduction to the SigPath ProjectInformation managementsignaling pathwaysontologydatabaseinformation management systemThis chapter reviews current approaches for managing signaling pathway information. After a brief introduction to ...
Fig. 4: FMRP modulates the WNT pathways regulating theWNT5BandCTNNB1mRNA metabolism. AEnrichment analysis of known FMRP target mRNAs and mutated in GBM according to The Cancer Genome Atlas. Shown are pathways that are significantly enriched in the PANTHER database (FDR < 0.05).BCluster hea...
Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther. 2002;1:777–83. CAS PubMed Google Scholar Abdelgalil AA, Al-Kahtani HM, Al-Jenoobi FI. Erlotinib. Profiles Drug Subst...
We have also clarified the roles of both the Wnt/β-catenin and Wnt spindle orientation signaling pathways in the control of ABar spindle positioning. Our results provide new insights into how multiple signals contribute to cell division. The Dshs and KIN-19 Regulate Orientation of the EMS ...
Evidence indicates that HMGB1 released by dead cells could exacerbate liver fibrosis caused by schistosome infection via modulating HMGB1-TLR2/4-NF-κB signaling pathways or activa- tion of HSC autophagy [31, 32]. The increased HMGB1 level in liver tissue of KOSJ group being significantly lower ...
5a–c). KEGG enrichment analysis demonstrated that these targets were mainly involved in inflammation-related signaling pathways, including IL-17, P53, PPAR, and NF-κB (Fig. 5d). Therefore, CO might improve RA by regulating the inflammatory response. Fig. 5 GO and KEGG pathway enrichment of...
cells, but not in GPR171KOJurkat cells (Fig.1i,j). We were able to confirm the suppressive effect of BigLEN on TCR-stimulated signaling pathways in primary human T cells (Supplementary Fig.2d,e). Altogether, our results suggest that BigLEN inhibits TCR-triggered signaling through human GPR...
C. Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol. Cancer Ther. 13, 855–866 (2014). Article CAS PubMed PubMed Central Google Scholar Li, X., Wu, J. B., Chung, L. W. & Huang, W. C...