the Signaling Pathways Project (SPP), that enhances the FAIR status of public cell signaling ‘omics datasets along three dimensions. Firstly, SPP encompasses datasets involving genetic
Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate functions of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates community ...
models that mimic multiple genetic defects in diseases; and targeted screening of critical genes or nucleotides of a specific gene involved in a developmental process. Recently, Li initiated a project to tag every protein in mice based on SC technology (genome tagging project, GTP), which may en...
Signaling pathways involved in the cell cycle regulation and DNA repair, epigenetic regulation, cell metabolism, tumor immunity and angiogenesis are recognized as targetable candidates [17], yet the corresponding clinical trials have progressed slowly with most failing to provide promising results. Notch ...
(973) Project and Qihuang Project. Former vice president of Xiyuan Hospital and director of Institute of Basic Medical Sciences of CACMS. Member of the national pharmacopoeia committee, project evaluation expert of Beijing and the National D...
In contrast, PD-L1 blockade could replenish the co-stimulatory signaling pathways between DC and CD8 T cells, which is compromised by PD-L1 expression on recurrent tumor cells. Together with emerging clinical trial data, our results suggested that tumor immunotherapy, combined with targeted therapies...
FMRP is upregulated in GSCs and regulates the expression ofWNT5BandCTNNB1mRNAs, pivotal in stem cells maintenance. Increased levels of FMRP lead to the aberrant activation of the WNT canonical and non-canonical signalling pathways affecting the transcription of genes related to cell proliferation. ...
Dogra C, Changotra H, Wergedal JE, Kumar A: Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch. J Cell Physiol. 2006, 208 (3): 575-585. 10.1002/jcp.20696. Article CAS...
Expression profile data of human cancer cell lines (CCLs) were obtained from the Broad Institute Cancer Cell Line Encyclopedia (CCLE) project (https://portals.broadinstitute.org/ccle/) [24]. Drug sensitivity data of human cancer cell lines (CCLs,https://portals.broadinstitute.org/ccle/) were...
We have also clarified the roles of both the Wnt/β-catenin and Wnt spindle orientation signaling pathways in the control of ABar spindle positioning. Our results provide new insights into how multiple signals contribute to cell division. The Dshs and KIN-19 Regulate Orientation of the EMS ...