As MAPK signal transduction pathways are one of the most attractive targets for cancer therapy, inhibitors that target this signaling appear to be promising drug candidates for the treatment of cancer. Here, we first give an overview of the use of yeast as a model system for drug discovery ...
3b). We identified apoptotic signaling pathways that are expected to be directly involved in mediating virus-induced CPE, as well as canonical interferon signaling that could impact CPE through modulation of cell proliferation or cell death pathways. We also found components of NF-κB-mediated ...
Furthermore, STM utilize signaling pathways, like AKT, FGF, MAPK, and WNT to mediate molecular functions coping with oxidative stress, toxin transport, DNA helicase activity, apoptosis and the cell cycle. Collectively, these data might explain the high therapy resistance of STM. Finally, we ...
(2002) High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 32:153–159 Article PubMed CAS Google Scholar Morse HC III, Qi C-F, Chattopadhyay SK, Hori M, Taddesse-Heath L, et al. (2001) Combined histologic and molecular features ...
Syringa pinnatifolia Hemsl. is a shrub belonging to the Oleaceae family. The peeled woody stems and roots of S. pinnatifolia are used in Chinese traditional medicine. This plant has been used for centuries, and modern pharmacological research has reveale
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5 B). One of the components of the LDM is vesicles containing the glucose transporter GLUT4 (13). In response to insulin these move to and fuse with the plasma membrane (reviewed in Ref. 14). We isolated GLUT4 vesicles from the LDM by immunoadsorption (13) and found by immunoblotting ...
The aim of this paper is thus to identify both the common and unique transport components across the major Drosophila transporting epithelia, using both a hypothesis-led approach, based on already known transport processes, and a hypothesis-free approach, based on enriched expression in one or ...
Contaminating CD34− cells (∼21%) allowed additional resolution of non-hematoendothelial niche components. 2,379 cells were clustered using a nonlinear dimensionality reduction technique, uniform manifold approximation and projection (UMAP), followed by the Leiden algorithm to produce 20 clusters (...
Environmentally inflicted stresses such as salinity and drought limit the plant productivity both in natural and agricultural system. Increasing emphasis has been directed to molecular breeding strategies to enhance the intrinsic ability of plant to survive stress conditions. Functional screens in microorganis...