High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet. 2002;32(1):153-159.High-throughput retroviral tagging to identify components of specific signal ing pathways in cancer. Mikkers H,Allen J,Knipscheer P,Romeijn L,Hart A,Vink E et al. ...
Depending on the nature of these pathways, unbiased genetic modifier screens may prove a productive way to identify novel redox-regulated signaling components.doi:10.1016/B978-0-12-405881-1.00012-4HurdThomas RyanMethods in Enzymology
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, Farah Ahmed, Jennifer A. Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey ...
For example, the 30 components of the root salt-sensitive module GaJAZ1a are significantly enriched in the dehydration stress26 and phytohormone response motifs (P-value < 0.05), illustrating that co-expressed genes may regulate the response of cotton to salt stress through phytohormone ...
"Cells are bags of proteins and other components like DNA. Different components are contained within intracellular compartments walled off by membranes. Imagine the cell as a house, and people within are proteins. Different groups of people spend more time in different places, depending on their jo...
Syringa pinnatifolia Hemsl. is a shrub belonging to the Oleaceae family. The peeled woody stems and roots of S. pinnatifolia are used in Chinese traditional medicine. This plant has been used for centuries, and modern pharmacological research has reveale
to be enriched in essential functions and in drug targets [18,19]. The implementation of network to assess molecules with impact on the biological pathways relevant to a disease is a useful strategy to prioritize genes and to address the function of the whole system and its components (modules...
In this study, a PCA of RNA-Seq expression data was computed and components that correlated with biological or technical variables (e.g. sex, feeding system, and date of pre-processing) were identified. Since the number of genes was large (> 12,000), it is advisable to perform a ...
2a). Since both GTP and ATP are also important components in RNA synthesis and metabolism, knockout of GUK1, PKM, and PGK1 will be highly lethal on the long-term; hence, the role of these genes in adhesion would be hard to validate by CRISPR-mediated knockout, but they also have ...
This study uncovers many host factors that are currently underappreciated, including the components of V-ATPases, ESCRT, and N-glycosylation pathways that modulate viral entry and/or replication. The cohesin complex is also identified as an anti-viral pathway, suggesting an important role of three...