As MAPK signal transduction pathways are one of the most attractive targets for cancer therapy, inhibitors that target this signaling appear to be promising drug candidates for the treatment of cancer. Here, we
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, Farah Ahmed, Jennifer A. Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey ...
Since both GTP and ATP are also important components in RNA synthesis and metabolism, knockout ofGUK1,PKM, andPGK1will be highly lethal on the long-term; hence, the role of these genes in adhesion would be hard to validate by CRISPR-mediated knockout, but they also have low clinical pot...
Oxidative stress affects major cellular components including lipids, DNA, and proteins. Through modulation of protein structure/function, ROS can influence gene expression profile by affecting intracellular signal transduction pathways. While several enzymatic and nonenzymatic markers of chronic oxidative stress...
Sucrose non-fermenting-1-related protein kinases (SnRK2.2, SnRK2.3, and SnRK2.6), the central components in the ABA signaling pathway, are activated following the perception of ABA and regulate ion transport, reactive oxygen species (ROS) production, and gene expression by phosphorylating different ...
The latter highlights one of the main advantages of this technique—the ability to explore contributions from genes in pathways critical for receptor presentation on the cell surface–and includes components such as transcription factors, trafficking proteins and post-translational modification enzymes. For...
ICA also enables separation of overlapping but distinct functional activity (Xu et al., 2015), which cannot be achieved by using atlas-based analysis. To overcome the limitation of ICA that components from different subjects might not have spatial correspondence, group ICA methods were developed (...
One limitation of the combinatorial weight function used in Dendrix and subsequent algorithms is that genes with high mutation frequencies (high coverage) can dominate the mutual exclusivity signal, thus biasing the algorithms towards identifying gene sets where the majority of the coverage comes from ...
Environmentally inflicted stresses such as salinity and drought limit the plant productivity both in natural and agricultural system. Increasing emphasis has been directed to molecular breeding strategies to enhance the intrinsic ability of plant to survive stress conditions. Functional screens in microorganis...
Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI patients. We hypothesized that transcriptional RN