High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 2002;32:331.Mikkers H, Allen J, Knipscheer P, Romeijn L, Hart A, Vink E, Berns A. High- throughput retroviral tagging to identify components of specific signal- ing pathways in cancer...
OPEN ORIGINAL ARTICLE Experimental & Molecular Medicine (2017) 49, e409; doi:10.1038/emm.2017.209 Official journal of the Korean Society for Biochemistry and Molecular Biology www.nature.com/emm Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a ...
This study uncovers many host factors that are currently underappreciated, including the components of V-ATPases, ESCRT, and N-glycosylation pathways that modulate viral entry and/or replication. The cohesin complex is also identified as an anti-viral pathway, suggesting an important role of three...
Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI patients. We hypothesized that transcriptional RN
Before performing GWAS, the phenotype was adjusted by year, sex, age, and the first two principal components (PCs) of the genotype generated by PLINK and normalized by rank-transformation using the transform function in GenABEL [36]. We performed an association test for each SNP based on a ...
Targets that were predicted to be repressed by RpaB were enriched in genes with a wide range of functionalities, such as nitrate assimilation, circadian clock, GTP binding, PSII reaction center subunits, and components of associated photosynthetic electron transport chains (Figure S3A). In contrast...
Oxidative stress affects major cellular components including lipids, DNA, and proteins. Through modulation of protein structure/function, ROS can influence gene expression profile by affecting intracellular signal transduction pathways. While several enzymatic and nonenzymatic markers of chronic oxidative stress...
3b). We identified apoptotic signaling pathways that are expected to be directly involved in mediating virus-induced CPE, as well as canonical interferon signaling that could impact CPE through modulation of cell proliferation or cell death pathways. We also found components of NF-κB-mediated ...
Since both GTP and ATP are also important components in RNA synthesis and metabolism, knockout ofGUK1,PKM, andPGK1will be highly lethal on the long-term; hence, the role of these genes in adhesion would be hard to validate by CRISPR-mediated knockout, but they also have low clinical pot...
One limitation of the combinatorial weight function used in Dendrix and subsequent algorithms is that genes with high mutation frequencies (high coverage) can dominate the mutual exclusivity signal, thus biasing the algorithms towards identifying gene sets where the majority of the coverage comes from ...