Signaling pathwaysTherapeuticsCancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of...
Genistein directly suppresses the activity of Akt and therefore this substance promotes the inactivation of its downstream signaling pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) [5,6,7]. The electrophoretic mobility shift assay further demonstrated that tr...
University of Life Sciences "King Mihai I" from Timisoara Read the Original This page is a summary of:Genistein as a regulator of signaling pathways and microRNAs in different types of cancers, Cancer Cell International, July 2021, Springer Science + Business Media, ...
In normal cells, the cell cycle is controlled by a series of signaling pathways by which a cell grows, replicates its DNA and divides. In cancers, as a result of mutations, this regulatory process malfunctions, resulting in uncontrolled cell proliferation that leads to carcinogenesis18,19. From...
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Intracellular signaling pathways: tyrosine kinase and mTOR inhibitors) Clin Microbiol Infect, 24 (2018), pp. S53-S70 View in Scopu...
Secreted type I IFNs bind to the IFNAR receptors in an auto- or paracrine fashion and activate the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, leading to the expression of a broad range of interferon-stimulated genes (ISGs), which are ultimate...
Certain morphological, physiological and molecular characteristics are shared by all neurons. However, despite these similarities, neurons constitute the most diverse cell population of any organism. Recently, considerable attention has been focused on i
There exists a commonality in the mechanisms of insulin signaling for acute induction of glucose uptake among different peripheral tissues that includes three separate critical nodes: 1) the insulin receptor and its associated substrates, 2) phosphoinositide 3-kinase (PI3K) and its subunits, and 3)...
Here, we describe an automated CUT&RUN platform and apply it to characterize the chromatin landscapes of human cells. We find that automated CUT&RUN profiles of histone modifications crisply demarcate active and repressed chromatin regions, and we develop a continuous metric to identify cell-type-sp...
There are many hypotheses as to why immunotherapy is not working for adult diffuse gliomas. Firstly, the anatomy of the CNS lends itself to unique immunological phenomena that don’t exist for other tumor types, such as the blood–brain barrier, meningeal inflammatory pathways, and glymphatic syst...