Key signaling pathways in atherosclerosis.aTLR signaling pathway. TLR stimulation triggers MyD88 to interact with IRAK4 (interleukin-1 receptor-associated kinase 4), which transmits signals into NF-κB and MAPK to activate the expression of inflammatory cytokines via the MyD88-dependent pathway. End...
activation of MAPK pathway, the upregulation of N-cadherin expression, and the potentiation of β-catenin signaling,99,100indicating that it acts as a nexus node coordinating multiple carcinogenic signals. Supplementary to intrinsic effect on tumor cell behavior, Notch activation is also highly associa...
近日,中山大学附属第三医院心血管内科研究团队在国际经典权威期刊Antioxidants and Redox Signaling上发表了题为“Lipotoxicity induces cardiomyocyte ferroptosis via activating the STING pathway”的研究论文,该研究通过体内外实验提供了铁死亡参与...
Wingless and int-1 (Wnt) signaling modulates the neural progenitor cell (NPC) self-renewal, proliferation, as well as differentiation in the brain at varying stages of CNS development. GBM along with other cancers (e.g., digestive system) is associated with aberrant Wnt pathway activity,157and...
Signal TransductionSynonymsSynonymsSignal transduction; Signaling pathwayDefinitionDefinitionSignal transduction pathway refers to a set of chemical reactions in a cell that converts a mechanical/chemical stimulus intodoi:10.1007/978-1-4419-9863-7_814Dr. Yufei Huang...
were given about classical signaling pathways which have been proved in other cancer types but not in LSCC, including PI3K signaling pathway, VEGF/VEGFR signaling and CDK4/6 pathway. Other signaling pathways which may have therapeutic potentials in LSCC were also discussed, including FGFR1 pathway,...
Figure 2. Overview of the application of the mating signal pathway in a synthetic biology paradigm. The pheromone-mediated signaling pathway in S. cerevisiae provides multiple elements for synthetic biology applications such as promoter engineering, metabolic engineering, biosensors, gene circuits, and ce...
Thesignal transduction pathwaythrough the IGF-IR is similar to that of IGF-I. Duringfetal development, signaling through INSR-A is of particular importance. The IGF-IIR/MPR has no known intrinsic kinase activity, and is thought to be ascavenger receptorinvolved in controlling the extracellular IG...
In addition to the JNK pathway, we also found that the NF-κB pathway was involved in the regulation of mPGES-1 and COX-2 in gingival fibroblasts stimulated with TNFα. Our results pointing out the NF-κB pathway in the regulation of mPGES-1 are in line with our previous observations [...
EngineeringSignalTransductionPathwaysEngineeringSignalTransductionPathwayispartofsyntheticbiologywithtwoobjective:•tounderstandhownaturalnetworksfunction•buildsyntheticnetworkswithspecificapplicationsorfunctionalitiesSyntheticbiologyisdividedintotwopart:EngineeringofGenecircuitsEngineeringofSignalingPathway Differencesbetween...