2022年10月,瑞金医院胸外科团队在国际知名学术期刊《Signal Transduction and Targeted Therapy》在线发表题为“Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials”——肺鳞癌信号传导通路和靶向治疗:机制和临床研究的综述论文。 瑞金医院胸外科李鹤成教授、上海市免...
some of which are related to the inhibition of nuclear factor-kappa-gene binding (NF-κB), β-arrestin-2 directly interacts with NF-κB inhibitor (IκBα), preventing the phosphorylation and degradation of IκBα.134However, this pathway is mainly related to anti...
In psoriasis, cytokines act on their target cells by binding to related membrane receptors to activate complex intracellular pathways. Among all the pathways, the NF-κB pathway, the MAPK pathway, and the JAK-STAT pathway are the most prominent ones to mediate cytokine signal transmissions across ...
近日,中山大学附属第三医院心血管内科研究团队在国际经典权威期刊Antioxidants and Redox Signaling上发表了题为“Lipotoxicity induces cardiomyocyte ferroptosis via activating the STING pathway”的研究论文,该研究通过体内外实验提供了铁死亡参与...
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase ...
Hedgehog signaling The Hedgehog signaling pathway regulates the proliferation and differentiation during embryonic development and is involved in early lung development through the epithelial mesenchymal interaction.91,92It is reported that the expression of signaling molecules in sonic Hedgehog pathway are up...
Signal TransductionSynonymsSynonymsSignal transduction; Signaling pathwayDefinitionDefinitionSignal transduction pathway refers to a set of chemical reactions in a cell that converts a mechanical/chemical stimulus intodoi:10.1007/978-1-4419-9863-7_814Dr. Yufei Huang...
A Novel Signal Transduction Pathway that Modulates rhl Quorum Sensing and Bacterial Virulence in Pseudomonas aeruginosa 来自 NCBI 喜欢 0 阅读量: 208 作者:C Qiao,Y Wang,F Chen,Y Xia,L Lan 摘要: Author Summary The rhl quorum-sensing (QS) system allows P. aeruginosa to regulate diverse ...
(1)Regad T. Targeting RTK signaling pathways in cancer. Cancers (Basel) 2015; 7: 1758–1784. (2)Waugh MG. Chromosomal instability and phosphoino-sitide pathway gene signatures in glioblastoma multiforme. Mol Neurobiol 2016; 53: 621–630. ...
<图6Schema depicting the function of the MUC1-C→NF-κB p65 pathway in integrating the induction of BCL2A1 expression with the EMT program and epigenetic regulation.> 参考文献 (1)Kufe, D. MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic appr...