2022年10月,瑞金医院胸外科团队在国际知名学术期刊《Signal Transduction and Targeted Therapy》在线发表题为“Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials”——肺鳞癌信号传导通路和靶向治疗:机制和临床研究的综述论文。 瑞金医院胸外科李鹤成教授、上海市免...
some of which are related to the inhibition of nuclear factor-kappa-gene binding (NF-κB), β-arrestin-2 directly interacts with NF-κB inhibitor (IκBα), preventing the phosphorylation and degradation of IκBα.134However, this pathway is mainly related to anti...
211 Furthermore, DUSP1/MKP-1, a negative regulator of the MAPK pathway, is found to be downregulated in psoriasis. The overexpression of DUSP1 can markedly inhibit keratinocyte proliferation and promote apoptosis by targeting the ERK signaling pathway.212 The PI3K-AKT pathway The PI3K/Akt pathway...
Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis: Journal of Receptors and Signal Transduction: Vo... Liu T, Feng X, Yang N, Zhou HF (2015) Signal- ing pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and...
Hedgehog signaling The Hedgehog signaling pathway regulates the proliferation and differentiation during embryonic development and is involved in early lung development through the epithelial mesenchymal interaction.91,92It is reported that the expression of signaling molecules in sonic Hedgehog pathway are up...
近日,中山大学附属第三医院心血管内科研究团队在国际经典权威期刊Antioxidants and Redox Signaling上发表了题为“Lipotoxicity induces cardiomyocyte ferroptosis via activating the STING pathway”的研究论文,该研究通过体内外实验提供了铁死亡参与...
Signal TransductionSynonymsSynonymsSignal transduction; Signaling pathwayDefinitionDefinitionSignal transduction pathway refers to a set of chemical reactions in a cell that converts a mechanical/chemical stimulus intodoi:10.1007/978-1-4419-9863-7_814Dr. Yufei Huang...
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
In addition to the JNK pathway, we also found that the NF-κB pathway was involved in the regulation of mPGES-1 and COX-2 in gingival fibroblasts stimulated with TNFα. Our results pointing out the NF-κB pathway in the regulation of mPGES-1 are in line with our previous observations [...
Cancer cells can activate diverse signaling pathways to evade the cytotoxic action of drugs. We created and screened a library of barcoded pathway-activating mutant complementary DNAs to identify those that enhanced the survival of cancer cells in the presence of 13 clinically relevant, targeted ther...