some of which are related to the inhibition of nuclear factor-kappa-gene binding (NF-κB), β-arrestin-2 directly interacts with NF-κB inhibitor (IκBα), preventing the phosphorylation and degradation of IκBα.134However, this pathway is mainly related to anti...
211 Furthermore, DUSP1/MKP-1, a negative regulator of the MAPK pathway, is found to be downregulated in psoriasis. The overexpression of DUSP1 can markedly inhibit keratinocyte proliferation and promote apoptosis by targeting the ERK signaling pathway.212 The PI3K-AKT pathway The PI3K/Akt pathway...
2022年10月,瑞金医院胸外科团队在国际知名学术期刊《Signal Transduction and Targeted Therapy》在线发表题为“Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials”——肺鳞癌信号传导通路和靶向治疗:机制和临床研究的综述论文。 瑞金医院胸外科李鹤成教授、上海市免...
Signal Transduction Pathway Thesignal transduction pathwaythrough the IGF-IR is similar to that of IGF-I. During fetal development, signaling through INSR-A is of particular importance. The IGF-IIR/MPR has no known intrinsic kinase activity, and is thought to be a scavenger receptor involved in...
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
近日,中山大学附属第三医院心血管内科研究团队在国际经典权威期刊Antioxidants and Redox Signaling上发表了题为“Lipotoxicity induces cardiomyocyte ferroptosis via activating the STING pathway”的研究论文,该研究通过体内外实验提供了铁死亡参与...
通路信号signalingapoptosis研究cst 信号通路研究cellsignalpathwaysCellSignalingTechnology,Inc(CST)是美国著名的生物公司和细胞信号转导研究的领袖,提供特色的信号转导检测用抗体及磷酸化抗体、ELISA试剂盒、激酶等产品。CST总部位于美国波士顿,毗邻哈佛、麻省理工等著名学府的雄厚人才资源,拥有专业的生产和研发队伍,发表的文章...
Signal pathways Elastase/SLPIaxisasabiologicalswitchinregulatinghostdefenseandwoundrepair AihaoDing,Ph.D.WeillMedicalCollegeofCornellUniversity WoundHealingModel NeutrophilsO2.- SLPIElastase Recruitment IL-8 Proepithelin MacrophagesEpithelialcells Epithelins Hostrecovery(tissuerepair®eneration)Growth Hostdefense(...
In addition to the JNK pathway, we also found that the NF-κB pathway was involved in the regulation of mPGES-1 and COX-2 in gingival fibroblasts stimulated with TNFα. Our results pointing out the NF-κB pathway in the regulation of mPGES-1 are in line with our previous observations [...
相关研究结果发表在Antioxidants Redox Signaling期刊上。该研究利用小鼠急性心肌梗死模型发现hESC-CVPCs可以改善心脏功能,减少心肌细胞凋亡,增加血管新生,减小心脏瘢痕面积,降低心梗急性期炎症水平并促进心梗后心脏巨噬细胞向修复型转变。进一步的机制研究发现hESC-CVPCs对巨噬细胞的极化调控是由其分泌的IL-4和IL-13介导的...