Researchers at Uppsala University and Harvard University have collaboratively developed a new theoretical model to explain how proteins can rapidly find specific DNA sequences, even though there are many obstacles in the way on the chromosomes. The findings are being published today in the scientific ...
How many different proteins, each with a unique amino acid sequence, can be constructed with a length of 8 amino acids?Amino Acid Sequence :An amino acid sequence is the specific, linear arrangement of amino acids of a peptide or protein. In natu...
A DNA sequence is 1500 nucleotides long. Answer the following questions: A) How many amino acids does this sequence code for? B) How many mRNA strands does this sequence code for? C) How many proteins does this sequence code for? D) Would it be m...
Protein coding features can emerge de novo in non coding transcripts, resulting in emergence of new protein coding genes. Studies across many species show that a large fraction of evolutionarily novel non-coding RNAs have an antisense overlap with protei
We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, “How many distinct primary structures of proteins (proteoforms) are created from the 20...
While many DNA-binding proteins directly "read out" the nucleotides of their recognition sequence, Cas1-Cas2 recognize the CRISPR repeat through more indirect means: its shape and flexibility. In addition to coding for proteins, the nucleotide sequence of a stretch of DNA also determines the mole...
a CRISPR RNA (crRNA) and a Cas protein. The crRNA contains information to target a specific DNA sequence . Thesemultidomain effector proteins achieve interference by complementarity betweenthe crRNA and the target sequence after recognition of the PAM (ProtospacerAdjacent Motif) sequence, which is ...
Many diseases are caused by an accumulation of unresolved DNA damage. Learn how DNA damage is recognized, which marker proteins initiate DNA damage response and what repair mechanisms exist
Highly conserved protein dimerization domains that occur in many proteins involved in membrane dynamics and act as connecting links between actin dynamics and membrane rearrangements in all eukaryotes. BAR domains preferentially bind to curved membrane regions. Chromatin Complex of genomic DNA with proteins...
Alleles are different versions of the same gene. In other words, alleles are different forms of a gene that arise due to mutations or changes in the DNA sequence of the gene. These mutations can occur spontaneously, or they can be inherited from parents...