How Proteins Bind DNA (And How Not To Model Them)Michael White
How do proteins assist in DNA replication? What two cell division processes use DNA replication? How many amino acids are involved in protein synthesis? How many DNA molecules will be found in each cell during prophase? How many double-stranded DNA molecules are in one chromosome?
How many base pairs are in 18S ribosomal RNA? How many different kinds of proteins does one cell contain? After three rounds of DNA replication, how many all-white DNA (both strands are white) will there be? Explain your reasoning.
To better understand DNA’s role in disease, scientists at Los Alamos National Laboratory have developed EPBDxDNABERT-2, a pioneering multimodal deep learning model. This model is designed to precisely identify interactions between transcription factors—proteins that regulate gene activity—and DNA. EPB...
Complex organisms, like plants and animals, have 50,000 to 100,000 genes on many different chromosomes (most humans have 46 chromosomes). In the cells of these organisms, the DNA is twisted around bead-like proteins called histones. The histones are also coiled tightly to form chromosomes, wh...
During mitosis, many proteins dissociate from chromatin and transcription shuts down. This may favour a silent PRE but challenge an active one. Several PcG and TrxG proteins remain bound to mitotic chromatin and may 'bookmark' silent and active states. Many PcG and TrxG target genes are dynami...
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in preclinical models and emerging evidence in humans have established the crucial roles of the innate and adaptive immune systems in driving atherosclerosis-associated chronic inflammation in arterial blood vessels. New te...
Many diseases are caused by an accumulation of unresolved DNA damage. Learn how DNA damage is recognized, which marker proteins initiate DNA damage response and what repair mechanisms exist
How many genes does the Human Genome contain? The Human Genome Project has revealed that there are probably about 20,000-25,000 'haploid' protein coding genes. The completed human sequence can now identify their locations. But only about 1.5% of the genome codes for proteins, while the rest...
The ability ofS. mutansto exert its pathogenicity is largely attributed to the production of EPS. EPS, a major component of biofilms38, consists of extracellular proteins, extracellular DNA, and lipoteichoic acid39. The primary component of EPS is glucan, which is synthesized by Gtf40, providing...