对文本和protein sequence进行对比学习,Lgc是为了最小化正样本的内积,最大化负样本的内积。 (3)Multimodal Mask Prediction 作者认为上面的训练没有捕捉到protein sequence中的residues(残基)和文本描述的联系,所以设计了一个fusion model: 对文本描述和protein sequence都使用15%的mask。 输入一个基于self和cross attent...
The method is applicable for the fold assignment of any protein sequence with or without significant sequence homology to known proteins. 该方法适用于倍转让任何蛋白质序列或无显着同源性已知的蛋白质。 www.syyxw.com 2. When a new gene is identified and its DNA sequence deciphered, it is still...
A collection of tasks to probe the effectiveness of protein sequence representations in modeling aspects of protein design protein protein-sequences representation-learning protein-design protein-function-prediction protein-fitness-prediction Updated Sep 30, 2024 Jupyter Notebook d...
While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc contains a basic-helix-loop-helix (bHLH) motif, which is important for dimerization and specific DNA binding,...
Multivalent protein-protein and protein-RNA interactions are the drivers of biological phase separation. Biomolecular condensates typically contain a dense network of multiple proteins and RNAs, and their competing molecular interactions play key roles i
Extraction of DNA, RNA, and protein is the basic method used in molecular biology. These biomolecules can be isolated from any biological material for subsequent downstream processes, analytical, or ...
Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and structure data have radically transformed computational protein design. New methods promise to escape the constraints of natural and laboratory evolution, accelerating the generation of proteins for applications in biotechno...
protein sequences by mass spectrometry, including step-by-step guidelines for sample preparation, analysis, and data interpretation. Michael Kinter and Nicholas Sherman present their own high-quality, laboratory-tested protocols for the analysis of a wide variety of samples, demonstrating how to carry...
DNA SEQUENCE FOR EXPRESSION IN AN E. COLI HOST OF A POLYPEPTIDE WITH THE PROPERTIES OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AND ITS USE IN THE PRODUCTION O... AR Banks,GM Fox 被引量: 0发表: 1991年 Human transforming growth factor-alpha: precursor structure and expression in E. coli. ...
'BLAST 2 Sequences', a new BLAST-based tool for aligning two protein or nucleotide sequences, is described. While the standard BLAST program is widely used to search for homologous sequences in nucleotide and protein databases, one often needs to compare only two sequences that are already kn...