图谱来自ProteinKG25,由Protein Sequence 和 Gene Ontology组成。 一文极速读懂 Gene Ontology (GO)数据库-腾讯云开发者社区-腾讯云 (tencent.com) Gene Ontology又有MFO (Molecular Function分子功能), CCO (Cellular Component细胞组分,即执行功能时所在的位置), or BPO (Biological Process生物过程) 文章的核心贡献:...
EvoTol: a protein-sequence based evolutionary intolerance framework for disease-gene prioritization 来自 万方 喜欢 0 阅读量: 114 作者:Rackham,JL Owen,Shihab,A Hashem,Johnson,R Michael,Petretto,Enrico 摘要: Methods to interpret personal genome sequences are increasingly required. Here, we report a ...
The target protein is expressed with sequence (Leu25-Gln167) of mouse PD-1 (Accession #NP_032824.1) fused with a 6×His tag at the C-terminus. 靶点背景信息 基因ID 18566 Swiss Prot Q02242 别名 CD279;mPD-1;SLEB2;PDCD1;PD1 瑾萱生物的重组蛋白表达和纯化及定制生产服务包括:重组蛋白大肠杆菌...
Significant progress has been made in protein structure prediction in recent years. However, it remains challenging for AlphaFold2 and other deep learning-based methods to predict protein structure with single-sequence input. Here we introduce trRosettaX
S1) (Figs. 2–3) and suggests that dynamics may be an important phenomena to study in protein aggregation-related diseases. The MBP NTD core encompasses residues that are far apart in sequence but juxta-positioned in the native state (Fig. 1a) and form the overall rate-limiting step in ...
LucaProt: A novel deep learning framework that incorporates protein amino acid sequence and structural information to predict protein function. - alibaba/LucaProt
Oligo(dA).oligo(dT) tracts are common intergenic sequences in many organisms. In the yeast Saccharomyces cerevisiae, these sequences have been shown to influence transcription of adjacent genes. We have purified an oligo(dA).oligo(dT)-binding protein from S. cerevisiae and cloned its gene. Thi...
【2.5】蛋白质序列空间(protein sequence space) In evolutionary biology, sequence space is a way of representing all possible sequences (for a protein, gene or genome). The sequence space has one dimension per amino acid or nucleotide in the sequence leading to highly dimensional spaces....
NCBI Antimicrobial Resistance Gene Finder (AMRFinderPlus) This software and the accompanying database are designed to find acquired antimicrobial resistance genes and point mutations in protein and/or assembled nucleotide sequences. We have also added "plus" stress, heat, and biocide resistance and vi...
Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and structure data have radically transformed computational protein design. New methods promise to escape the constraints of natural and laboratory evolution, accelerating the generation of proteins for applications in biotechno...