Although the existing works on DNA motif discovery on DNA sequences are plethoric, mechanistic knowledge to infer DNA motifs from protein sequences across multiple DNA-binding domain families without conducting any wet-lab experiments is still lacking. Therefore, the k-spectrum recognition modeling is...
One of the main challenges in applying machine learning algorithms to biological sequence data is how to numerically represent a sequence in a numeric input vector. Feature extraction techniques capable of extracting numerical information from biological sequences have been reported in the literature. How...
While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc contains a basic-helix-loop-helix (bHLH) motif, which is important for dimerization and specific DNA binding,...
Transfer RNA • Transfers amino acids to the ribosome to make protein Transcription: Getting the message out of the nucleus • Transcription = enzymes make RNA by copying a portion of DNA in the nucleus • If a DNA sequence is AATCCGGA, what is the complimentary RNA sequence? • UU...
The target protein is expressed with sequence (Leu25-Gln167) of mouse PD-1 (Accession #NP_032824.1) fused with a 6×His tag at the C-terminus. 靶点背景信息 基因ID 18566 Swiss Prot Q02242 别名 CD279;mPD-1;SLEB2;PDCD1;PD1 瑾萱生物的重组蛋白表达和纯化及定制生产服务包括:重组蛋白大肠杆菌...
The task of protein sequence design is central to nearly all rational protein engineering problems, and enormous effort has gone into the development of energy functions to guide design. Here, we investigate the capability of a deep neural network model to automate design of sequences onto protein...
LucaProt: A novel deep learning framework that incorporates protein amino acid sequence and structural information to predict protein function. - alibaba/LucaProt
A polymorphism in the repetitive (TGGA)n sequence 5' to the human myelin basic protein gene in Italian multiple sclerosis patients. Guerini FR, Losciale L, Mediati M, et al. A polymorphism in the repetitive (TGGA)n sequence 5’ to the human myelin basic protein gene in Italian multiple ...
Evolution of sequence, structural and functional diversity of the ubiquitous DNA/RNA-binding Alba domain Jaiganesh Jagadeesh Shruthi Sridhar Vembar ResearchOpen Access05 Dec 2024 Scientific Reports Volume: 14, P: 30363 Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ...
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