A protein is a sequence of amino-acids which forms a long and thin string-like molecule. This string twists and turns to fold into a ball that is susp..Abdellah Salhi
The task of protein sequence design is central to nearly all rational protein engineering problems, and enormous effort has gone into the development of energy functions to guide design. Here, we investigate the capability of a deep neural network model to automate design of sequences onto protein...
The protein sequence of a representative of the zeins, the major storage proteins of maize, has been derived from the nucleotide sequence of a zein cDNA cl... G Dan,MA Peifer,I Rubenstein,... - 《Nucleic Acids Research》 被引量: 2414发表: 1981年 Repetitive extragenic palindromic sequences...
Since the introduction of MacVector’sCloning Clipboard,all cloning actions (such as ligating a digested fragment into a vector) create a/FRAGfeature that records the source of the ligated fragment, the restriction enzymes used to digest it (and any end treatment such as Klenow) as well as a ...
the protein coded by a short open reading frame, not by the annotated coding sequence is the main gene product of the dual-coding gene mief1 V Delcourt,M Brunelle,AV Roy,... 被引量: 0发表: 2019年来源期刊 Molecular & Cellular Proteomics 站内活动 ...
A preprint version of the article is available at bioRxiv.Abstract Significant progress has been made in protein structure prediction in recent years. However, it remains challenging for AlphaFold2 and other deep learning-based methods to predict protein structure with single-sequence input. Here we...
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation. It has been shown that expression of the RIa subunit of cyclic AMP (cAMP)-dependent protein kinase is enhanced in human cancer cell lines...
Protein alignments are an essential tool for many bioinformatics analyses. While sequence alignments are accurate for proteins of high sequence similarity, they become unreliable as they approach the so-called 'twilight zone' where sequence similarity ge
Comparison of the median activities of the individual TF consensus sequences revealed that several TFs had enhancer activity in GP5d cells (Fig. 1c, Extended Data Fig. 1a–c, Supplementary Note and Supplementary Table 5). The consensus sequence corresponding to the p53 protein family (p53, p63...
In animal systems, each of the three G-protein subunits belong to large multigene families; however, few subunits have been isolated from plants. Here we report the cloning of a second plant G-protein γ-subunit (AGG2) from Arabidopsis thaliana. The predicted AGG2 protein sequence shows 48%...