Department of Chemistry and Chemical BiologyProteins: Structure, Function, and BioinformaticsRackovsky S. Sequence determinants of protein architecture. Proteins. 2013; 81:1681-5.Rackovsky S. Sequence determinants of protein architecture. Pro- teins: Structure, Function & Bioinformatics 2013;81:1681-...
Learning Sequence Determinants of Protein:protein Interaction Specificity with Sparse Graphical Models. In studying the strength and specificity of interaction between members of two protein families, key questions center on which pairs of possible partners a... H Kamisetty,B Ghosh,CJ Langmead,... ...
For the FTase and the GGTase-I activities, the C-terminal amino acid sequence of the protein substrate, the CAAX box, appeared to contain all the critical determinants for interaction with the transferase. In fact, tetrapeptides with amino acid sequences identical to the C-terminal sequences ...
Sequence determinants of protein phase behavior from a coarse-grained model. PLoS Comput. Biol. 14, e1005941 (2018). Article PubMed PubMed Central Google Scholar Dignon, G. L., Zheng, W., Kim, Y. C. & Mittal, J. Temperature-controlled liquid–liquid phase separation of disordered ...
Sequences of putative soluble proteins from complete genomes of eight thermophiles and 12 mesophiles were analyzed to gain insight into determinants of protein thermostability. The predator algorithm was used to assign secondary structures to each protein sequence. Based on simple statistical tests, a ...
DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space th
The discovery of methods for programmable genome editing by CRISPR-Cas9 systems have offered unprecedented capabilities for comprehensive genetic perturbations in situ to investigate the sequence determinants of gene function. We have developed a widely adaptable open-source computational tool, CRISPRO, to...
However, the phage genome has not been exploited as a source of additional resistance determinants. A 4.5-kb BamHI-HindIII fragment of phage nck202.5... C Hill,LA Miller,TR Klaenhammer - 《Journal of Bacteriology》 被引量: 144发表: 1990年 Physical mapping of beta-converting and gamma-non...
W. Characterization of RNA sequence determinants and antideterminants of processing reactivity for a minimal substrate of Escherichia coli ribonuclease III. Nucleic Acids Res. 34, 3708–3721 (2006). 20. Lunde, B. M., Moore, C. & Varani, G. RNA-binding proteins: modular design for efficient ...
Material properties of phase-separated biomolecular condensates, enriched with disordered proteins, dictate many cellular functions. Contrary to the progress made in understanding the sequence-dependent phase separation of proteins, little is known about the sequence determinants of condensate material propertie...