The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J. Immunol. 176, 43–51 (2006). CAS PubMed Google Scholar Kanaya, T. & Ohno, H. The mechanisms of M-cell differentiation. Biosci. Microbiota Food ...
13,14. However, the source of homeostatic IgE-producing B cells in BALB/c mice has been enigmatic. As IgE class-switching requires IL-4 and the frequency of NKT2 cells is highest in the thymus
Montero et al., "Bacterial stim- ulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal paneth cell 𝛼-defensins," Journal of Innate Immunity, vol. 5, no. 1, pp. 39-49, 2013.Menendez A, Willing BP, Montero M, Wlodarska M, So CC, Bhinder G, Vallance BA,...
Immunity, 41 (2014), pp. 152-165 10.1016/j.immuni.2014.05.016 1:CAS:528:DC%2BC2cXhtFeqsb%2FK, 25017466 Google Scholar 32 Y Cong, T Feng, K Fujihashi, TR Schoeb, CO Elson A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota Proc. Natl Acad. Sci. USA...
Herein, we show that under steady-state conditions, the absence of PD-1 signaling led to a preferential expansion of CD8+ T cells in the liver. These cells exhibit an oligoclonal T cell receptor (TCR) repertoire and a terminally differentiated exhaustion profile. The transcription factor EOMES ...
Physiologic features such as the development of innate and adaptive immunity, relative susceptibilities to infections, immune tolerance, bioavailability of nutrients, and intestinal barrier function may be modified by changing the composition and functions of the microbial communities. The specialty of ...
Recent evidence suggests that the pathogenesis of DM is related to immune mechanisms, including abnormalities in cellular and humoral immunity [6,7,8]. CD4+ helper T cells (T helper cells, Th) play an important role in the immune response [9, 10]. CD4+ T cells are thought to have a ...
Here, we show that large peritoneal macrophage (LPM) display impairs efferocytosis in broad-spectrum antibiotics (ABX)-treated, vancomycin-treated and germ-free mice in vivo, all of which have a depleted gut microbiota. Mechanistically, the microbiota-derived short-chain fatty acid butyrate directly...
Similarly, human DC2s in skin expressed an IL-4 and IL-13 gene signature that was not found in blood, spleen and lung DCs. In mice, IL-13 was secreted homeostatically by dermal innate lymphoid cells and was independent of microbiota, TSLP or IL-33. In the absence of IL-13 signaling,...
Type I interferons (IFNs) are key molecules in innate immunity, the first line of defense against infection and sterile insults. In response to microbial or endogenous DNA or RNA, pattern recognition receptors initiate signaling pathways, including cGAS-STING, RIG-I/MDA5-MAVS, and TLR3/4, tha...