The host-microbiota relationship, therefore, is typically characterised as one of cooperation and mutualism, where both sides receive considerable benefits10. This characterisation has led to the conception of a host and its microbiota as a single evolutionary or organisational unit, sometimes known as ...
The interaction between the metabolic activities of the intestinal microbiome and its host forms an important part of health. The basis of this interaction is in part mediated by the release of microbially-derived metabolites that enter the circulation.
Despite our growing understanding of the impact of this host-microbe alliance on immunity in the gastrointestinal tract, the extent to which individual microenvironments are controlled by resident microbiota remains unclear. In this Perspective, we discuss how resident commensals outside the ...
Mehta, M., Weinberg, S. & Chandel, N. Mitochondrial control of immunity: beyond ATP.Nat Rev Immunol17, 608–620 (2017). https://doi.org/10.1038/nri.2017.66 Download citation Published03 July 2017 Issue DateOctober 2017 DOIhttps://doi.org/10.1038/nri.2017.66 ...
For instance, oral infections with Toxoplasma gondii in certain inbred strains of mice lead to an exacerbated intestinal inflammation that is accompanied by a loss of diversity within the gut flora. Furthermore, the microbiota was shown to aggravate the immunopathology of the disease. The mechanisms...
Passive immunity to coronavirus and rotavirus infections in swine and cattle: Enhancement by maternal vaccination CV cause localized infections of the respiratory and/or intestinal tracts, with the exception of feline infectious peritonitis virus (FIVP) and hem... LJ Saif 被引量: 34发表: 1985年 ...
A mounting body of evidence indicates that dietary fiber(DF)metabolites produced by commensal bacteria play essential roles in balancing the immune system.DF,considered nonessential nutrients in the past,is now considered to be necessary to maintain adequate levels of immunity and suppress inflammatory ...
Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1 + mono...
Overall, we identify a novel role for the microbiota in shaping immunity, which includes induction of CCL2 levels that control homeostatic trafficking of pDCs. INTRODUCTION Plasmacytoid dendritic cells (pDCs) are a subset of DCs recognized for their ability to detect viral genomes through Toll-like...
Although much research has been done on the diversity of the gut microbiome, little is known about how it influences intestinal homeostasis under normal and pathogenic conditions. Epigenetic mechanisms have recently been suggested to operate at the interface between the microbiota and the intestinal epit...