As an essential nutrient, iron has a direct impact on the immune system1,2, and iron deficiencies and iron overload are thus closely related to immune disorders3,4. Notably, iron deficiencies are frequently observed in patients with inflammatory bowel diseases (IBDs, including Crohn’s disease ...
Additionally, the bacterial signals may promote cancer development by inhibiting local antitumor immunity.96For example,F. nucleatumwithin the CRC is negatively associated with the density of CD3+T-cell infiltrated in the TME, which relates to the downregulation of antitumor adaptive immunity.104One th...
108 Because postbiotics comprise the spectrum of compounds produced by microorganisms, they act on health via the gut-microbiota–CVD axis broadly by modulating gut-microbiota composition, boosting innate immunity, decreasing pathogen-induced inflammation, and enhancing the survival of intestinal epithelial...
Additionally, the bacterial signals may promote cancer development by inhibiting local antitumor immunity.96For example,F. nucleatumwithin the CRC is negatively associated with the density of CD3+T-cell infiltrated in the TME, which relates to the downregulation of antitumor adaptive immunity.104One th...
Therefore, to establish KBL375 as a potential immune-boosting agent, this study aims to investigate the efficacy of KBL375 in NK cell activation and its effects on the immune responses and intestinal microbiome in cyclophosphamide (CP)-treated mice. Materials and Methods Preparation of KBL375 ...
Oxaliplatin is the latest platinum-based chemotherapeutic agent and recommended as the first-line regimen for the treatment of advanced cancer of the colon and rectum.11 Oxaliplatin exerts its anticancer effect mainly via forming platinum-DNA abducts to elicit cell death and inhibit DNA replication.12...
CTLs contribute to anti-tumor immunity by directly killing tumor cells or by regulating the activity of other immune cells. Flow cytometry was used to measure the percentage of CD3+CD8+ cells, which reflects the infiltration of CTLs in the tumors. As presented in Fig. 8B and Fig. S14, ...
[2]. The infectious agent,Helicobacter pylori(H. pylori), is widely recognized as the most influential contributor to the onset of GC. An estimated 50% of people worldwide are infected withH. pylori[3] and approximately 90% of GC on a global scale result from the inflammation and damage ...
harnessing intratumor microbiota as therapeutic targets would present innovative strategies to complement existing cancer treatments (Fig.5), such as (1) modulating microbial composition to reinvigorate anti-tumor immunity; (2) engineering bacteria to deliver therapeutic payloads directly to tumors or conve...
need for a comprehensive and in-depth understanding of the current research progress in intratumoural microbiota, this review summarises the characteristics and emerging functions of intratumoural microorganisms in various tumours as well as their effects on cancer development and antitumour immunity. We...