The initial gastric colonizers can shape the local and systemic immunity in early life. In animal models, it has been demonstrated that the offspring of mothers who were given antibiotics during pregnancy and breastfeeding had a decrease in microbial diversity in gastric contents accompanied by elevat...
the gastrointestinal tract, particularly the colon, stands out as the largest microecosystem, harboring several trillion microbial cells [2]. Moreover, the gene set among the
need for a comprehensive and in-depth understanding of the current research progress in intratumoural microbiota, this review summarises the characteristics and emerging functions of intratumoural microorganisms in various tumours as well as their effects on cancer development and antitumour immunity. We...
As an essential nutrient, iron has a direct impact on the immune system1,2, and iron deficiencies and iron overload are thus closely related to immune disorders3,4. Notably, iron deficiencies are frequently observed in patients with inflammatory bowel diseases (IBDs, including Crohn’s disease ...
Numerous herbal and spice ingredients exhibit antimicrobial properties and prebiotic-like effects, presenting a potential application in preventive medicine for boosting innate immunity, mitigating pathogen-induced enteritis, and modulating harmful gut microbiota and their metabolites (Elumalai et al., 2020; ...
(complete or partial response or stable disease status) as their best response, while theNRgroup showed disease progression as their best response to the administered systemic treatment. The patients in the two groups were similar in terms of stage of cancer, sex, age, and therapy type (Table...
thus inducing tumor proliferation and metastasis.bMechanisms of microbes instigating tumorigenesis and tumor suppression in the TME: (1) Immunity boosting: For example, bacterial metabolites can elevate IFN-γ-producing CD8 + T cells, enhance the therapeutic effect of ICIs in mouse models, and ...
Rouse discovered that avian sarcoma can be transmitted in animals through filtered cell-free tumour extracts which suggested that causative agent in the tumour extracts, roussarcoma virus, could induce cancer, thereby establishing viruses as the causal agents of cancer for the first time.15In 1964,...
thus inducing tumor proliferation and metastasis.bMechanisms of microbes instigating tumorigenesis and tumor suppression in the TME: (1) Immunity boosting: For example, bacterial metabolites can elevate IFN-γ-producing CD8 + T cells, enhance the therapeutic effect of ICIs in mouse models, and ...
it is necessary to thoroughly evaluate their safety before clinical use. Probiotics may pose a risk to individuals with damaged barriers or low immunity, such as bacteremia128because high concentrations of administration are key to medication. Regarding the cariogenic issue, after conducting a meta-...