European Society of Blood and Marrow transplantation EBV: Epstein-Barr virus FHL: familial HLH HLH: hemophagocytic lymphohistiocytosis LA-HLH: lymphoma-associated HLH MAS: macrophage activation syndrome MOF: multiorgan failure NK cell: natural killer cell ...
HLH is one of the complications in dengue infection. A 69-year-old lady was treated for severe dengue with multi-organ dysfunction with superimposed pneumonia, requiring mechanical ventilation. However, persistent cytopenia despite blood transfusion without evidence of haemorrhage raised the suspicion of...
Pediatr Blood Cancer. 2007;48:124-131 [3] Carter SJ, Tattersall RS, Ramanan AV. Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment. Rheumatology (Oxford). 2019;58(1):5-17. [4] Ramos-Casals M, Brito-Zer贸n P, L贸pez-Guillermo A, Khamas...
Hemophagocytic Lymphohistiocytosis (HLH) is a severe and rapidly progressive immune disorder that can be life threatening if not diagnosed and treated promptly. The HLH2004 guidelines, originally devised for the diagnosis of HLH in pediatric subjects, lack due utility in the adult population. Despite ...
S Ramachandran,MPaed,H Ariffin - 《Pediatric Blood & Cancer》 被引量: 17发表: 2010年 Successful use of Infliximab in macrophage activation syndrome with severe CNS affection Macrophage activation syndrome (MAS) is a secondary form of haemophagocytic lymphohistiocytosis (HLH) seen in childhood in ...
Familial hemophagocytic lymphohistiocytosis (HLH) is a rare primary immunodeficiency disorder characterized by defects in cell-mediated cytotoxicity that results in fever, hepatosplenomegaly, and cytopenias. Familial HLH is well recognized in children but rarely diagnosed in adults. We conducted a ...
Consecutively, HLH was suspected as blood sampling revealed increased serum levels of ferritin, triglycerides, the soluble IL-2 receptor and a decrease in fibrinogen levels. In the initial course of disease, the highest ferritin value measured was 1032 ng/mL (reference range 22–112 ng/mL) and...
Although HLH-2004 criteria were created for children and initially had not been validated for adults, the “HLH in adults“ Working Group of the Histiocyte Society recommended these diagnostic criteria in conjunction with clinical data [4]. After the publication of the recommendation, different ...