6.Naval D, et al. Patients (pts) with Optimized Hemophagocytic Lymphohistiocytosis (HLH) Inflammatory (OHI) Index-Confirmed Diagnosis of Malignancy-Associated HLH (mHLH) and Emapalumab Treatment. 2024ASH#3913. 7.Johnson WT, et al. E...
In the last 10-15 years, secondary HLH has been increasingly recognized in adults, where it is frequently associated with lymphoid malignancy, infection, or autoimmune disease. This relatively recently recognized diagnosis and the treatment of adult HLH have been largely shaped by observations in ...
Inclusion criteria for the AOSD group included adults with a diagnosis of AOSD admitted to hospital with AOSD flare, based on Yamaguchi criteria (see Supplementary Table 2). MS scores were also calculated for AOSD patients using Wang’s cutoff of > -1.08 for MAS/HLH in AOSD (see Supplementary...
2015, 16 Suppl 1:S5.18. Döhner H, et al.Diagnosis and management of AML in adults: 2017...
BS was sent to a larger center for nephrology consult and renal biopsy. The renal biopsy was diagnostic for focal lupus nephritis (class 3) and the patient was started on mycophenolate. DISCUSSION: HLH and SLE are both challenging diagnosis in the pediatric population and can have significant mo...
We conducted a retrospective study of 23 adults treated with etoposide-based therapy compared to 10 pediatric HLH cases at a single center. At diagnosis, the median serum ferritin was 20,071 g/L and 937 g/L in adults and children, respectively; median sIL-2r was 14,524 U/mL and 4,...
(A) sIL-2r in diagnosis of adult HLH; (B) ferritin in diagnosis of adult HLH; and (C) sIL-2r and ferritin in diagnosis of HLH. sIL-2r levels have been correlated with disease activity in previous studies, and recommendations have been made to monitor sIL-2r levels during the course...
Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: A systematic scoping review Most knowledge of hemophagocytic syndromes (HPSs) Giustini,Dean,Lee,... - 《Blood Reviews》 被引量: 23发表: 2016年 Current Updates on Classification, Diagnosis and Treatment of Hemo...
Such a phenomenon of hyperinflammation can be either familial or acquired in origin with the most common causes including infection, autoimmune disease, malignancy, and immunosuppression [2]. Acquired HLH, also known as secondary HLH, is an aggressive clinical entity requiring early diagnosis and ...
Together with the identification of 1 bp deletion in exon of SH2D1A, a diagnosis of HLH could be accepted. However, it is interesting to note that the gene SH2D1A is located on the X chromo- some [11] and Sanger sequencing revealed that the mutation was heterozygous in the mother, ...