研究设计 比较有相同基础疾病但无HLH(疾病对照组[disease controls, DC])和健康对照组(healthy controls, HC)的自然杀伤(natural killer, NK)细胞毒性进行系统性评估,包括患者体外总淋巴细胞计数和亚型、NK细胞表型、穿孔素表达和脱颗粒、...
and genetic predisposition differs in age groups with enrichment of familial disease in children and enrichment of malignant disorders as underlying condition and/or trigger in adults. These differences plus differential tolerance of drugs due to age and comorbidity guide the recommended aHLH treatment ...
In the last 10-15 years, secondary HLH has been increasingly recognized in adults, where it is frequently associated with lymphoid malignancy, infection, or autoimmune disease. This relatively recently recognized diagnosis and the treatment of adult HLH have been largely shaped by observations in ...
HR Freeman,AV Ramanan - 《Archives of Disease in Childhood》 被引量: 190发表: 2011年 Haemophagocytic lymphohistiocytosis complicating Hodgkin's lymphoma in an HIV-positive individual. HIV, lymphomas, EBV infection and haemophagocytic syndrome have a complicated pathophysiology. Unfortunately, HLH in thi...
[1] Wenyuan Lai, Yini Wang, Jingshi Wang, Lin Wu, Zhili Jin & Zhao Wang (2018) Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults and adolescents—a life-threatening disease: analysis of 133 cases from a s...
(from the time of patient's hospitalization until the patient's death) and due to fact that the majorities of the demises were performed in the first 5 weeks, two another variables were chosen: extremely severe disease (demises in the first month) and severe disease (demises in the first...
Antibody-dependent enhancement of severe dengue disease in humans Science (80-.) (2017) Google Scholar Cited by (0) 1 Institution Address: Royal Free Hospital, Pond Street, Hampstead Heath, London NW3 2QH, UK. Generated by, an expert-curated chemistry database. ...
2、 疾病缓解(non-active disease):需达到以下标准。 体温正常; 脾脏大小恢复(少数病人可持续存在单纯性脾脏轻度肿大);外 14、周血象恢复 (Hb90g/L,PLT100 109/L, ANC1.5 109/L); 甘油三酯水平恢复(3mmol/L); 血清铁蛋白500g/L; 脑脊液正常(针对初诊时脑脊液阳性的病例); (对于有检测条件者,sCD25水平...
We report a series of three cases which showcase the spectrum of liver disease as presentation in hemophagocytic lymphohistiocytosis.关键词: HLH children liver disease CMV, cytomegalovirus EBV, Epstein Barr virus HLH, hemophagocytic lymphohistiocytosis LKM, liver–kidney-microsomal MAS, macrophage ...
2、 疾病缓解(non-active disease):需达到以下标准。 体温正常; 脾脏大小恢复(少数病人可持续存在单纯性脾脏轻度肿大); 外周血象恢复 (Hb≥90g/L,PLT≥100× 109/L, ANC≥1.5× 109/L); 甘油三酯水平恢复(<3mmol/L); 血清铁蛋白<500μg/L; 脑脊液正常(针对初诊时脑脊液阳性的病例); (对于有检测条件者,...