HLA-DR+ NK cells are functionally active: they produce proinflammatory cytokines, degranulate, and easily proliferate in response to stimuli. Additionally, HLA-DR+ NK cells seem able to take in and then present certain antigens to CD4+ and CD8+ T cells, inducing their activation and ...
HLA-I由MHC-I编码,将胞内的抗原呈递到细胞表面,被CD8 T(killer T cell)细胞识别并消灭细胞;HLA-II类基因靠近染色体着丝粒端centromere,主要包括HLA-DR, DP, DQ几个基因。HLA-II由MHC-II编码,将细胞外抗原呈递给CD4 T(T-helper cells 辅助T细胞),T细胞增殖,进而刺激B细胞产生抗原特异性抗体(体液免疫)。因为...
43. HLA-DR EXPRESSION, NK CELLS AMD IgE COHTAINING CELLS IN THE JEJUNAL NUCOSA OF COELIAC CHILDRENPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. ...
1、HLA-DR是MHC-II类分子，含有2个分子量分别为36kD和27kD的亚基（α亚基和β亚基）。2、HLA-DR表达于B淋巴细胞、单核细胞、巨噬细胞、活化T淋巴细胞、活化NK淋巴细胞和人祖细胞上。3、它也表达于胸腺上皮细胞、脾和淋巴结的B淋巴细胞依赖区及B淋巴细胞淋巴瘤。4、HLA-DR与CD1a共同表达于表皮...
Patients with critical HFMD had the lowest HLA-DR expression ( P<0.05). ② The numbers of CD14 + monocytes, CD3 + T cells, CD4 + T cells, CD8 + T cells, B cells and NK cells in peripheral blood of the DR-L group were significantly lower than those of the DR-N group and the ...
结论NHL患者外周血单核细胞CD14+HLA-DRlow/-提示预后不良,检测CD14+HLA-DRlow/-单核细胞对于评估患者疾病进展、预测患者预后具有重要的参考价值。 关键词: 淋巴瘤,非霍奇金;单核细胞;HLA-DR抗原 ABSTRACT ObjectiveTo assess the immune function of newly diagnosed patients with non-Hodgkin lymphoma (NHL), and...
(2)增殖反应阶段:供体和移植抗原刺激受体的Th细胞发生增殖,并产生IL-2、IL-4、IL-5、IL-6、IL-9和IFN-γ等多种细胞因子,为B细胞和杀伤性T细胞前体(CTLp)增殖和分化提供条件,并促进Mφ和NK细胞的杀伤功能。HLA-I类抗原和Ⅱ类的DR、DQ抗原经巨噬细胞处理后分别刺激CTLp和B细胞,分化为效应CTL和抗体产生细胞...
Frozen sections from 30 secondary carcinomas (22 intra- and 8 extradural) were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, NK cells and HLA-Dr invariant chain. A moderate number of macrophages was demonstrated in 91% of tumours. CD 8 and CD 4 lymphocytes were ...
On T cells, NK cells, hematopoietic precursor cells, and some epithelial cells the expression of HLA-DR is induced by cell activation. For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130...