Hemophagocytic lymphohistiocytosis (HLH)-like episode in which the natural killer (NK) cell activity was persistently low from early infancy but returned to normal at the age of 3 years has been described.doi:info:doi/10.1111/ped.13803Fujiki, Toshihiro...
Signaling pathways in T/NK-cell proliferation. NF-κB pathway in EBV-positive T-cell lymphoma: a diagrammatic depiction of the pathogenesis and molecular mechanisms associated with progression from hemophagocytic lymphohistiocytosis (HLH) to chronic active disease or T-cell lymphoma in Epstein–Barr viru...
These results shift the current paradigm on the role of ID2, indicating that it is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15. 展开 ...
为此,国内北京友好医院的Zhao Wang等人发表在2月1日的Int J Hematol上的文章《Application of an improved flow cytometry‑based NK cell activity assay in adult hemophagocytic lymphohistiocytosis》中提出了用平时比较容易得到的EGFP标记的K562细胞作为靶细胞,以Annexin V/PI双标,通过流式细胞术定量检测EGFP-K562的...
[11]AlterG,MalenfantJM,AhfeldM,eta1.CD107aasa 本研究的不足之处和局限性:①由于 EBV.HLH发病 functionalmarkerforthe identification of natural killer cell 机制不清,临床诊断困难,且人选病例需要未经过化疗的患 activity.ImmunolMethods,2004,294(1):15-22 [12]YucR,JohnR.RoleofasTATBindingSiteintheReug...
Despite this, we did not find the post-pandemic JDM group to have higher disease activity scores or any significant change in disease severity. Interestingly, both of the patients with known antecedent COVID-19 infections had lower NK cells (1% and 3% respectively) than the average NK cell ...
While degranulation activity of NK cells is decreased in NBAS-deficient patients, expression levels of granzyme B and perforin remain widely unchanged. We speculate that impaired STX18 complex function in NBAS- associated disease might impair NK cell cytotoxicity by dis- turbing granule release of ...
Their activity in CAR T cells has yet to be validated in large clinical trials. It has been found that the intracellular CD28 and 4-1BB domains have different effects on CAR T cell differentiation and metabolism [18, 19]. A combination of 4-1BB and CD3ζ induces the central memory T ...
TCRδ subunit of their stereotyped Vγ1.1Vδ6.3 TCR complex; however, when E protein activity is enhanced by Id3-deficiency and the Trav15d-1-dv6d-1 element is eliminated, then the Trav15-1-dv6-1 element is capable of supporting NKγδT cell development through a Vγ1.1Vδ6.1 TCR ...
Their activity in CAR T cells has yet to be validated in large clinical trials. It has been found that the intracellular CD28 and 4-1BB domains have different effects on CAR T cell differentiation and metabolism [18, 19]. A combination of 4-1BB and CD3ζ induces the central memory T ...