The NK cells that accumulated in immune deciduas were not proliferating cells since they did not stain for Ki67. Given that uNK cell numbers typically decline after mid-gestation (E11.5), we speculate that newly recruited killer cells come from peripheral blood. This is supported by our observat...
CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods. 294, 15–22 (2004). 7. Doh, J., Kim, M. & Krummel, M. F. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials 31, 3422–3428 (...
在这样一个实施例中,于2004年7月1日提交的、名称为“Composition and methods forregulating NK cell activity(用于调节NK细胞活性的组合物和方法)”的PCT专利申请PCT/FR 04/01702中描述的任何抗体都可以相应地用于本发明,将其披露的内容通过引证合并于本文中。 在本发明的一个特定目的中,该阻断NK细胞的抑制性受体...
Protein-bound polysaccharide (PSK) induces cytotoxic activity in the NKL human natural killer cell line. Int J Clin Lab Res 1999; 29: 135–140. Article CAS PubMed Google Scholar Nagashima S, Mailliard R, Kashii Y, Reichert TE, Herberman RB, Robbins P et al. Stable transduction of the ...
Activation of accessory cells leads to the production of cytokines that contribute to the functional activation of NK cells, while sens- ing of PAMPs by NK cells themselves further enhances NK cell reactivity. All listed cytokines have been shown to amplify NK cell activity, either alone or in ...
BioXCell热销产品—InVivoMAb anti-mouse NK1.1 克隆号PK136单克隆抗体能与小鼠NK1.1(也称为CD161b/CD161c、KLRB1、NKR-P1A和Ly-55)反应。NK1.1是一种具有C型凝集素结构域II型整合膜糖蛋白,由Klrb1c/NKR-P1C基因编码。NK1.1在NK细胞活化和分化、IFN-γ产生、细胞毒性颗粒释放中起作用,被认为参与Th2细胞的...
These changes in NK cell distributions had an important effect on the deregulation in the functional activity of this cell compartment at different stages of infection. Finally, individuals with nonprogressive chronic HIV-1 infection who maintain normal NK cell subset distributions also manifest adequate...
Souza-Fonseca-Guimaraes, F. et al. NK cells require IL-28R for optimal in vivo activity.Proc. Natl Acad. Sci. USA112, E2376–E2384 (2015). ArticlePubMedCASPubMed CentralGoogle Scholar Rajagopalan, S. HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproductio...
Finally, we identify a role for CD56 in developmental synapse structure, NK cell motility and NK cell development. Thus, we define the developmental synapse leading to human NK cell functional maturation. 1 Center for Human Immunobiology, Baylor College of Medicine and Texas Children's Hospital, ...
Natural killer cell activity and head and neck cancer: a clinical assessment. J. Natl Cancer Inst. 77, 869–875 (1986). CAS PubMed Google Scholar Strayer, D. R., Carter, W. A. & Brodsky, I. Familial occurrence of breast cancer is associated with reduced natural killer cytotoxicity. ...