T-cell lymphomas encompass several hematological cancers in children and adolescents. Arising in cells of the innate and adaptive immune systems, T- and natural killer (NK)-cell neoplasms comprise over 20 distinct entities in the current World Health Organization (WHO) schema (Table 1andFigure 1)...
T-cell lymphomas encompass several hematological cancers in children and adolescents. Arising in cells of the innate and adaptive immune systems, T- and natural killer (NK)-cell neoplasms comprise over 20 distinct entities in the current World Health Organization (WHO) schema (Table 1andFigure 1)...
data$seurat_clusters,function(x){cell_type[cell_type$cluster==x,'type']})) DimPlot(data_150825,reduction = 'tsne',group.by = 'type',label = T) data_150825_nk <- subset(data_150825,subset= type == 'NK cell') data_150825_nk <- NormalizeData(data_150825_nk) data_150825_nk <- ...
tumor cells80,81, sensitized pediatric high-grade gliomas to virotherapy in preclinical models13. The combination of oncolytic viral therapy with NK cell therapy can also result in a synergistic, therapeutic effect against brain tumors. The combination of bortezomib, a proteasome inhibitor, oHSV, an...
To further test the hypothesis that individuals lacking expression of CD32 on their NK cell are homozygous for STP allele, we investigated the correlation between the level of CD32 expression and the genotype of these two donors. RT-PCR experiments on RNA obtained from NK cells from these two...
Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of eng...
Phenotypic expression of natural killer cell associated membrane antigens and cytolytic function of peripheral blood cells from different aged humans J. Clin. Lab. Immunol. (1986) N. Bloushtain Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp...
expressed genes (DEG) within each cluster, with genes having a q-value < 1e5 being used to order the cells in pseudo time analysis. Subsequently, the constructed cell trajectories were examined for differentially expressed genes along the pseudotime using the “differentialGeneTest” function. ...
Using a specialized cell-laden microwell approach, we discover that NK cells experiencing constant NK-to-NK contact exhibit a synergistic increase in activation status, cell proliferation, and anti-tumor function in response to IL-2 or IL-15. This effect is dependent on 2B4/CD48 ligation and ...
These findings suggest that HBV might directly interfere with NK-cell function in a RIG-I-dependent manner, which dampens the activation of both NF-κB and p38. Cellular & Molecular Immunology Hepatitis B virus impairs NK cell functions via exosomes Y Yang et al 473 Figure 7 Schematic of ...