为了评估 HLA-C/KIR 相互作用是否会影响 NK 亚群的扩增,研究者们根据供受者 KIR 配体的组合,将患者分为3组,第1组的供者和受者均为C1C1、第2组的供者和受者均为C1C1BW4,第3组的供者和受者均为C1C2BW4并且分析了 NKG2...
KIR2DS1和HLA-C的作用 在采用异基因造血干细胞移植(HSCT)治疗的癌症中,急性髓性白血病(AML)对自然杀伤(NK)细胞的反应最敏感。激活的杀伤细胞免疫球蛋白样受体(KIR)2DS1具有对HLA-C2抗原的配体特异性,并以HLA依赖的方式激活NK细胞。由KIR2DS1和HLA调控的供体NK细胞反应可能对异基因HSCT治疗的AML患者有益。来自美...
NKQ-PCRInteraction of donor natural killer (NK)-cell-associated killer cell immunoglobulin-like receptors (KIRs) with the patient's human leukocyte antigen-C (HLA-C) ligands can result in an alloreactive NK response after haematopoietic stem cell transplantation. In many retrospective studies, ...
Interaction of donor natural killer (NK)-cell-associated killer cell immunoglobulin-like receptors (KIRs) with the patient's human leukocyte antigen-C (HLA-C) ligands can result in an alloreactive NK response after haematopoietic stem cell transplantation. In many retrospective studies, additional HLA...
In this review, we focus on the unique role of HLA-C in regulating NK cell functions and its consequences in the setting of viral infections. 展开 关键词: HLA-C NK cells killercell immunoglobulin-like receptors viral infection HLA-C NK cells killercell immunoglobulin-like receptors viral ...
在采用异基因造血干细胞移植(HSCT)治疗的癌症中,急性髓性白血病(AML)对自然杀伤(NK)细胞的反应最敏感。激活的杀伤细胞免疫球蛋白样受体(KIR)2DS1具有对HLA-C2抗原的配体特异性,并以HLA依赖的方式激活NK细胞。由KIR2DS1和HLA调控的供体NK细胞反应可能对异基因HSCT治疗的AML患者有益。来自美国Sloan-Kettering癌症中心...
HLA-C分 cell 子为NK细胞免疫球蛋白样受体(1dller immuIloglobulill.1ikereceptor,10R)的配 体之一,可在免疫调节中发挥重要作用。根据l诹特异性识别HLA.C位点第80位 合和分离的速率均较快,在正常生理情况下,抑制性ⅪR与HLA.C分子快速结合 而产生的抑制信号占据主导地位,从而有效抑制NK细胞对正常组织细胞的杀伤...
Natural killer (NK) cells are fast-acting and versatile lymphocytes that are critical effectors of innate immunity, adaptive immunity, and placental development. Controlling NK cell function are the interactions between killer-cell immunoglobulin-like receptors (KIRs) and their HLA-A, HLA-B and HLA...
More recently a new function has been identified for HLA class I molecules where they act as inhibitors of the lytic capacity of natural killer (NK) cells and non-MHC-restricted T-cells. Moreover, the understanding of this novel mode of negative regulation of cytotoxicity was remarkably ...
百度试题 结果1 题目载肽后高亲与力结合CD94/NKG2A致NK细胞抑制得分子就是 A. HLA-A B. HLA-B C. HLA-C D. HLA-G E. HLA-E 相关知识点: 试题来源: 解析 E 反馈 收藏