NK疗法被认为是一种现货型疗法,无需进行HLA的匹配——Martin Maiers,国际血液骨髓移植研究中心CIBMTR VP, https://bethematchbiotherapies.com/cell-lines-blog/hla-matching-for-allogeneic-cell-therapies/ “NK细胞不会介导GVHD,因此他们无需进行供体和受体的匹配来发挥功能”https://doi.org/10.1016/j.beha.2016....
Pre-clinical and clinical studies have demonstrated safety and efficacy of allogeneic NK cells against various malignancies—both hematological and solid tumors, without the need for strict HLA-matching. Several clinical trials are currently ongoing which use NK or C...
Transplantation over HLA barriers may trigger natural killer (NK)–cell alloreactivity based on “missing-self” recognition. This can occur when the recipient lacks 1 or more of the major inhibitory killer cell immunoglobulin-like receptor (KIR)–binding HLA motifs present in the donor.1,2 In ...
NK cell tolerance towards autologous healthy cells is mediated by HLA-specific inhibitory NK receptors (iNKR), mainly represented by KIRs and CD94/NKG2A (Moretta et al., 1996). Inhibitory KIRs (iKIRs) are type I molecules of Ig superfamily, characterized by 2 or 3 extracellular domains and...
NK细胞疗法,全称为自然杀伤细胞疗法,是先天免疫系统的一部分,可以靶向下调HLA-I类分子的癌细胞,这些细胞毒性淋巴细胞的任务是监视应激细胞,使它们成为我们抵御病毒感染细胞和异常细胞的第一道防线。 NK细胞属于过继性细胞治疗的一种方式,因为它们不需要完全的HLA匹配,从而降低了...
入组后,患者先接受了淋巴细胞清除化疗(氟达拉滨+环磷酰胺),随后接受了单次回输源自脐带血且HLA不匹配的抗CD19CAR-NK细胞。研究的中位随访期为13.8个月(随访时间范围:2.8~20.0个月)。 研究结果令人惊喜:客观缓解率(ORR)高达73%(...
目前T细胞治疗必须是自体的,只能使用患者自己的T细胞。这是因为异体T细胞与人类白细胞抗原(HLA)复合物相互作用可能导致致命细胞因子释放综合症或移植物抗宿主病。相比之下,NK细胞对HLA复合物的选择要少得多。因此,使用自体或异体的NK细胞不会产生严重的副作用也不需要与患者免疫匹配,更容易被临床应用。
Hilton, H.G.; Parham, P. Missing or altered self: Human NK cell receptors that recognize HLA-C. Immunogenetics 2017, 69, 567-579. [CrossRef] [PubMed]Hilton HG & Parham P (2017) Missing or altered self: human NK cell receptors that recognize HLA-C. Immunogenetics 69: In press...
In fact, five clinical trials use NK-92 cell lines in human patients. In one trial using HLA-mismatched CAR NK therapy developed from cord blood, none of the 11 patients developed GVHD [79]. Hence, one major advantage of CAR NK therapy is that an “off-the-shelf” ready-to-use CAR ...
1). Therefore, NK cell killing of a target cell depends on the balance between inhibitory and activating signals. Tumour cells that down regulate expression of human leukocyte antigen (HLA) are more susceptible to the NK cell killing due to a reduced KIR mediated inhibition. Download: Download ...