J. (2006) Dynamic changes in histone H3 lysine 9 methylations. Identifica- tion of a mitosis-specific function for dynamic methylation in chromo- some congression and segregation. J. Biol. Chem. 281, 8888 - 8897
In this study, we investigate the epigenetic profiles of patients with pterygium, focusing on histone H3 lysine 4 (H3K4) and lysine 9 (H3K9) trimethylation (me3). While H3K4me3 levels showed no significant genome-wide change, they were significantly altered in genes related to development and oc...
OBJECTIVES: We have examined dynamic changes of histone H3 lysine 9 following trimethylation (H3K9me3), the mRNA expression levels of SUV39H1 and SUV39H2 in bovine oocytes and the role in the development of in vitro fertilization (IVF) pre-implantation embryos. RESULTS: There were strong H3K9...
articles Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons Violaine Saint-André1–3, Eric Batsché1–3, Christophe Rachez1–3 & Christian Muchardt1–3 Pre-messenger?RNAs?(pre-mRNAs)?maturation?is?initiated?cotranscriptionally.?It?is?therefore?conceivable?that?
We profiled the repressive mark histone H3 lysine 9 trimethylation (H3K9me3) genome-wide in peripheral blood mononuclear cells (PBMCs) from 18-week-old infants (n = 15) and mothers (n = 14) enrolled in the PROVIDE study established in an urban slum in Bangladesh. We associated ...
In germinal center B (GCB) cells, EZH2 is highly expressed and mediates the transcriptional repression of several tumor suppressor genes by catalyzing their H3K27 trimethylation17. However, it remains unknown whether and how histone modification regulates B-cell activation, proliferation, and ...
The -fold enrichment of H3K9me3 that was normalized with that of histone H3 and IgG is plotted. Each bar is an average of biological triplicates. Error bars show S.E. I, ChIP experiments were done with asynchronous (black bars) and G1/S (gray bars)-blocked HEK-293-FLAG-PIP5K cells...
A simplistic model has been proposed that, confirmed more recently through genome-wide sequencing analyses, trimethylation of histone H3 lysine 4 (H3K4Me3) heralds transcriptional activation, whereas trimethylation of H3 lysine 9 (H3K9Me3) leads to trans-repression. SUV39H, short for suppressor of ...
Global H3-K9 trimethylation and DNA methylation at IAP repeats in Eset(-/-) blastocyst outgrowths were not dramatically altered. Together, these results suggest that Eset is required for peri-implantation development and the survival of ES cells....
phosphorylation at Serine 9 ONLY in Histone H3. Western Blot of acid extracts of HeLa cells (1) and recombinant histone H3.3 (2), using RM162 at 0. 01 ug/mL, showed a band of histone H3 modified by both trimethylation at lysine 9 and phosphorylation ...