Lysine methylation of the histone tail is involved in a variety of biological events. G9a and GLP are known as major H3-K9 methyltransferases and contribute to transcriptional silencing. The functions of these
Lysine methylation occurs primarily on histones H3 (Lys4, 9, 27, 36, 79) and H4 (Lys20) and has been implicated in both transcriptional activation and silencing (4). Methylation of these lysine residues coordinates the recruitment of chromatin modifying enzymes containing methyl-lysine binding ...
Within ~1 kilobase upstream or downstream of the TSS of cyclin E1, BCR or TLR stimulation greatly reduced the levels of H3K9 tri- and di-methylation (H3K9me3/2) in control B cells, whereas in iron-deficient B cells, H3K9me demethylation of cyclin E1 was severely inhibited (Fig. 7e)....
Here we found that in the mouse V(H) locus, methylation of lysine 9 on histone H3 (H3-K9), a mark of inactive chromatin, was present in non-B lineage cells but was absent in B cells. As others have shown that H3-K9 methylation can inhibit V(D)J recombination on engineered ...
Combined, these data provide evidence for a key role of the meK9H3-G9a pathway as a mediator of the oncogenic Kras response and defines a novel point of potential therapeutic intervention for PDAC. Support or Funding Information NIH R01CA178627; NIH R01DK58185; Advancing a Healthier ...
Histone methylation on lysine (K) residues can function to either activate or repress gene expression, depending on which lysine residues are methylated. In general, methylations at K4, K36, and K79 of histone H3 are involved in the activation of transcription, whereas methylations at K9 and ...
zeste, and Trithorax proteins. Lysine methylation occurs primarily on histones H3 (Lys4, 9, 27, 36, 79) and H4 (Lys20) and has been implicated in both transcriptional activation and silencing. Methylation of these lysine residues coordinates the recruitment of chromatin modifying enzymes containing...
Histone H3 lysine 9 (H3K9) dimethylation is a critical mark for gene silencing and plays an essential role in embryogenesis and carcinogenesis. In this study, we investigated the effects of acute hypoxic stress on H3K9 dimethylation expr... H Chen,Y Yan,TL Davidson,... - 《Cancer Research...
Lysine methylation occurs primarily on histones H3 (Lys4, 9, 27, 36, 79) and H4 (Lys20) and has been implicated in both transcriptional activation and silencing. Methylation of these lysine residues coordinates the recruitment of chromatin modifying enzymes containing methyl-lysine binding modules ...
6). Here we show that HP1 can bind with high affinity to histone H3 methylated at lysine 9 but not at lysine 4. The chromo domain of HP1 is identified as its methyl-lysine-binding domain. A point mutation in the chromo domain, which destroys the gene silencing activity of HP1 ...