One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this modification is found at the promoters of actively transcribed genes. The total levels of H3K4me3 are increased in the CA1 region of the hippocampus during memory ...
The JmjC domain, initially identified in the C-terminal region of the mouse Jumonji protein, is now known to mediate the demethylation of histone lysine residues3,4. Histone demethylation by JmjC domain containing proteins in vitro requires αK G, which is converted to succinate in the ...
In particular, histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic marks of active transcription. Whilst many studies have provided evidence of the correlation between H3K4me3 and active transcription, details regarding the mechanism involved remain unclear. The first ...
H2Bub1 is localized across the body of active genes21and is closely coupled to transcriptional elongation22,23,24,25. Studies in both yeast and human cells have revealed a coupling of H2Bub1 and the trimethylation of lysines 4 and 79 of histone 3 (H3K4me3 and H3K79me3, respectively) nea...
Discussion Analysis of ChIP‑Seq peaks Histone H3 lysine 4 trimethylation (H3K4me3) has been used as an active mark to identify histone modifications associated with drought-responsive genes in Arabidopsis [21, 41]. A substantial increase in H3K4me3 activity in response to heat stress has been...
Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-activated genes in Neuros
(Lewis, Elsaesser, Noh, Stadler, & Allis, 2010). The poised regions into which histone H3.3 is placed are enriched for lysine 4 trimethylation of H3 (H3K4me3), or for both lysine 27 trimethylation (H3K27me3) and H3K4me3(Delbarre et al., 2010). Thus the deposition of mutant histones ...
we find alcohol-induced increases in sperm histone H3 lysine 4 trimethylation (H3K4me3) that map to promoters and presumptive enhancer regions enriched in genes driving neurogenesis and craniofacial development. Given the colocalization of H3K4me3 with the chromatin binding factor CTCF across both sperm ...
histone H3 Lys 27 trimethylationlncRNA‐ATBovarian cancerpolycomb repressive complex 2Ovarian cancer (OC) remains one of the most lethal gynecological malignancies. The unfavourable prognosis is mainly due to the lack of early﹕tage diagnosis, drug resistance and recurrence. Therefore, it needs to ...
g9a介导的histone h3 lysine9甲基化作用在自噬调控中的分子基础论文 热度: set1-catalyzed h3k4 trimethylation antagonizes the hirasf1rtt106 repressor complex to promote histone gene expression and chronological life span.[ 热度: Letter https://doi/10.1038/s41586-019-1016-7 ...