Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B (2018) Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers. Cell Res 28: 387...
Here, we show that the enhancer-specific histone H3 lysine 4 monomethylation (H3K4me1) and the histone methyltransferases MLL3 and MLL4 (MLL3/4) play an active role in this process. We demonstrate that in differentiating mouse embryonic stem cells, MLL3/4-dependent deposition of H3K4me1 at ...
As with all other histone lysine methylations, methylation of histone H3 on lysine-4 exists in mono, di, or tri methylated (H3K4me1, 2, 3) forms, and these modification states control differing mechanistic outputs through the recruitment of H3K4me-specific binding proteins. Significant ...
Monomethylation ofhistoneH3-lysine 4 (H3K4me1) plays an important role for neuronal activity-induced transcription at enhancer sequences (Kim et al., 2010). The highermethylationforms of H3K4, H3K4me3 and H3K4me2 are primarily found at the 5′end of genes, with H3K4me3 mostly arranged as dis...
Epigenetic mechanisms are fundamental to understanding the regulatory networks ofgene expression that govern stem cell maintenance and differentiation. Methylated histone H3 lysine 4 (H3K4) has emerged as a key epigenetic signal forgene transcription; it
Mono-Methyl-Histone H3 (Lys4) Rabbit Polyclonal Antibody -20ºC保存,Western一抗稀释液-20ºC或4ºC保存,一年有效。Western一抗稀释液优先推荐4ºC保存,长期不使用可以考虑-20ºC保存,但冻融可能会导致出现轻微的浑浊和少量不溶物。 注意事项: ...
Furthermore, histone H3 lysine 4 trimethylation (H3K4 me3) is observed more strongly in the regulatory regions of pluripotency genes in transplanted nuclei that are rapidly reprogrammed than in nuclei that are reprogrammed slowly and are not seen in β-globin, a gene that is not reprogrammed. ...
Using chromatin immunoprecipitation and deep sequencing (ChIP-Seq) we established the whole-genome distribution patterns of histone H3 lysine 4 mono-, di-, and tri-methylation (H3K4me1, H3K4me2, and H3K4me3, respectively) in Arabidopsis thaliana during watered and dehydration stress conditions. In ...
Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS (complex of proteins associated with Set1) family from Saccharomyces cerevisiae to humans, and these modifications can be found at distinct regions of the genome. Monomethylation of histone H3K4 (H3K4me...
lysine. Much like theenzymesthat modifyhistones(the “writers”,Box 2), the factors that bind to the modifications (the “readers”) are highly specific. For example, the chromo domain ofheterochromatinprotein 1 (HP1) binds only methylated K9 withinhistone H3, whereas the similar domain in ...