Profiling more than 2,500 ex vivo drug responses across 27 patients and 132 drugs identified class-diverse neuroactive drugs with potent anti-glioblastoma efficacy that were validated across model systems. Interpretable molecular machine learning of drug–target networks revealed neuroactive convergence on ...
Immunoserological parameters in SLE: high-avidity anti-dsDNA detected by ELISA are the most closely associated with the disease activity. Clin Rheumatol 2013;32:1619-26. PMID: PM:23857662Andrejevic S, Jeremic I, Sefik-Bukilica M, Nikolic M, Stojimirovic B, Bonaci-Nikolic B. Immuno...
K dsDNA and albumin tests included n = 3 technical test replicates. The numbers displayed on a bar graph represent the exact numerical values of the bar. Clar clarification, Concen concentration, Guard Filt guard filtration, Chrom chromatography, Buffer Ex buffer exchange, Sterile Filt sterile...
anti-inflammatory function is important for adaptation to extreme environments [36] and intestinal protection of the host. Previous studies indicated that the role of probiotics in the gut mainly presented in the ileum where inflammation
Test for statistical significance was performed using the Student’s two-tailed unpaired t-test and P<0.05 was considered significant. Abbreviations BSA: bovine serum albumin C1-INH: C1-inhibitor DC: dendritic cells dsDNA: double-stranded DNA HSP90α: heat shock protein 90 α HMGB1: ...
Telomeres are the protective nucleoprotein structures at the end of linear eukaryotic chromosomes. Telomeres’ repetitive nature and length have traditionally challenged the precise assessment of the composition and length of individual human telomeres.
Another recent study also identified differences between patients with Alzheimer’s disease and normal controls in 11 genera from the feces and 11 genera from the blood (Li et al., 2019). Given the emerging reports that link the gut microbiota to brain function, it seems possible that maternal...
Bottom: expression is measured by staining the cells with anti-FLAG, sorting high- and low-expression populations, sequencing the domains, and computing the log2(FLAGhigh:FLAGlow) ratio. (E) Distribution of FLAG staining levels measured by flow cytometry before and after sorting into 2 bins (...
Tests included blood routine examination, including HbA1C, fasting blood glucose, triglyceride, and cholesterol, as well as hepatic and renal function analyses by automatic biochemical analyzers according to standardized national quality control protocols. To analyze the plasma metabolome, 5 mL of ...
The objective response rate of microsatellite-stable colorectal cancer (MSS-CRC) patients to anti-PD-1 or anti-PD-L1 therapy is low32, and this low clinical activity may be explained by a limited number of neoantigen-specific T cells33. To test the applicability of our TCR library screening...