1 promotes the expression of hundreds of genes involved in cell autonomous and non-autonomous adaptations to hypoxia. Examples of genes and their functions are found in the diagram. HIF-α can be upregulated at the protein level via mTOR or at the mRNA level via STAT3 and NF-κB signaling....
令其他研究| QITAYAN 』 U运动干预抗癌机制: HIF - la 信号通路调控作用的研究进展The Mechanism of Anticancer Action of Exercise Intervention : the Research Progress on the Regulatory Role of HIF - la Signaling Pathway孔健达 , 穆玉晶 , 朱磊 Kong Jianda , Mu Yujing,Zhu Lei摘 要:近年来 , 有...
an independent prognostic variable for poor overall survival. In conclusion, our data indicated that the TFRC-involved HIF-1 signaling pathway may play a crucial role in cervical cancer. We thank Juan Chen from CCN department of ZTE for her computer technology support. This work was supported by...
Hypoxia inducible factor-1 α (HIF-1α) is the key responser adapted to tumor hypoxia. Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis. Activation of HIF-1α signaling has been...
HeLa细胞;miR-600;HIF-1α;细胞增殖;血管内皮生长因子 Abstract: Objective To determine whether miR-600 suppresses the proliferation of HeLa cells by inhibiting hypoxia-inducible factor-1α (HIF-1α) signaling pathway and its effect on expressions of cyclin D1 and vascular endothelial growth factor ...
可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应, 在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点.对转录因子 HIF-1α 及其信号通路在疾病发生 中的作用进行了综述,介绍了 HIF-1α 在动物生长发育,炎症和肿瘤中的研究概况,并进行了展望,以便...
qPCR was used to investigate the expression level of stem cell markers after hypoxia in lung adenocarcinoma cells and the role of Notch1 signaling pathway in the process. We further explored the expression of the stem cell markers in lung adenocarcinoma cell line with stable expression of HIF-1...
Gel shift assay showed that HIF-1 bound to the promoter sequence of Sost directly. These findings support our hypothesis that HIF-1α activates Sost expression. This study provides a novel molecular mechanism through which HIF-1α inhibits Wnt signaling in osteoblasts. 展开 ...
3.2基于HIF-1信号通路分析复方治疗心肌缺血的分子机制 基于前期收集的活性成分潜在靶点,利用DAVID数据库进行单味药材的KEGG通路富集分析, 见表2~5。结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K...
通过对 HIF-1α 与恶性肿瘤细胞生物学特性之间的关系研究,发现其表达的调控可能存在氧依赖和非氧依赖两种基本的调控通路,且非氧依赖的调控通路可能发挥更多样的调节作用。 氧浓度变化以及生长因子水平等可通过氧依赖和非氧依赖调控通路激活相关信号从而上调 HIF-1α 表达。氧依赖通路主要是指 VHL(von Hippel-Lindau)...