NCT00436254: Vaccine Therapy With Sargramostim (GM-CSF) in Treating Patients With HER2 Positive Stage III-IV Breast Cancer or Ovarian Cancer (A Phase I Study of a DNA Plasmid Based Vaccine Encoding the HER-2/Neu Intracellular Domain in Subjects With HER2...
NCT00436254: Vaccine Therapy With Sargramostim (GM-CSF) in Treating Patients With HER2 Positive Stage III-IV Breast Cancer or Ovarian Cancer (A Phase I Study of a DNA Plasmid Based Vaccine Encoding the HER-2/Neu Intracellular Domain in Subjects With HER2/Neu Overexpressing Tumors) 该单中心非随...
1. What is the impact of HER2 levels in HER2-positive metastatic BC patients treated with standard therapy? 2. Is there room for targeting HER2-negative tumors with low HER2 expression (meaning cases with IHC score 1+ or 2+ not amplified by FISH)? Starting from the first question, the le...
A logistic regression model was applied to analyze the connection between pre- and post-operative clinicopathological factors and the presence of positive nonsentinel additional axillary lymph nodes (non-SLN+). Using LASSO regression (LR), the variables necessary for a predictive score of non-SLN+ ...
Slamon D, Eiermann W, Robert N (2006) BCIRG 006: Second interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in Her2neu positive ear...
Seidman, MD JAMA Oncology Key Points Question Are the effects of a proposed trastuzumab biosimilar equivalent to those of trastuzumab in the treatment of ERBB2 (formerly HER2 or HER2/neu)–positive metastatic breast cancer? Findings In this randomized clinical trial that included 458 women, the ...
Targeted therapies have profoundly changed the clinical prospect in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. In particular, the anti-HER2 monoclonal antibody trastuzumab represents the gold standard for the treatment of HER2+ breast cancer patients. Its contribution in damp...
HER2: Human Epidermal growth factor Receptor 2, HER2/neu iDCs: Immature dendritic cells mDCs: Mature dendritic cells MNCs: Mononuclear cells (meaning monocyte-depleted non-adherent fraction of peripheral blood mononuclear cells) PBMCs: Peripheral blood mononuclear cells PI: Propidium iodide ...
The MUC1-positive tumor cell may be a carcinoma cell, a leukemia cell or a myeloma cell. The carcinoma cell may be a prostate or breast carcinoma cell. The peptide may be is fused to a cell delivery domain, such as poly-D-R, poly-D-P or poly-D-K. The peptide may be ...
The family of ERBB transmembrane receptor tyrosine kinases (RTKs) consists of the four members EGFR (ERBB1), HER2 (Neu, ERBB2), HER3 (ERBB3) and HER4 (ERBB4), which fulfill essential functions during development (Citri et al., Nat. Rev. Mol. Cell Biol., 2006, 7(7), 505-516; ...