NCT00436254: Vaccine Therapy With Sargramostim (GM-CSF) in Treating Patients With HER2 Positive Stage III-IV Breast Cancer or Ovarian Cancer (A Phase I Study of a DNA Plasmid Based Vaccine Encoding the HER-2/Neu Intracellular Domain in Subjects With HER2...
NCT00436254: Vaccine Therapy With Sargramostim (GM-CSF) in Treating Patients With HER2 Positive Stage III-IV Breast Cancer or Ovarian Cancer (A Phase I Study of a DNA Plasmid Based Vaccine Encoding the HER-2/Neu Intracellular Domain in Subjects With HER2/Neu Overexpressing Tumors) 该单中心非随...
Growing evidence suggests a clear role of the host immune system in HER2+ breast cancer. In addition, HER2+ breast cancer is generally considered more immunogenic than hormone receptor-positive (HR+)/HER2-, and specific molecular HER2+ subgroups (e.g. HE
Slamon D, Eiermann W, Robert N (2006) BCIRG 006: Second interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in Her2neu positive ear...
Targeted therapies have profoundly changed the clinical prospect in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. In particular, the anti-HER2 monoclonal antibody trastuzumab represents the gold standard for the treatment of HER
Overexpression of the human epidermal growth factor receptor 2 (HER2) as a result of HER2 gene amplification is associated with a relatively poor prognosis in breast cancer and is predictive of HER2-targeting therapy response. False-positive rates of up
Maier et al., “Requirements for the Internalization of a Murine Monoclonal Antibody Directed against the HER-2/neu Gene Product c-erbB-2,” Cancer Res., Oct. 1, 1991, 51:5361-5369. Needleman et al., “A General Method Applicable to the Search for Similarities in the Amino Acid Sequence...
HER2/neu protein is a receptor-like transmembrane protein comprising a large cysteine-rich extracellular domain that functions in ligand binding, a short transmembrane domain, and a small cytoplasmic domain. HER2/neu is amplified and expressed in many human cancers, largely adenocarcinomas of breast, ...
Human epidermal growth factor receptor-2 (Her2/ErbB2), also known as Her2/Neu, ErbB-2, CD340 or p185, is a protein encoded by human Her2 gene. Her2 is a receptor tyrosine kinase (RTK) belonging to the epidermal growth factor receptor (EGFR/ErbB) family. It consists of 1255 amino acid...
As used herein the term “HER2” has its general meaning in the art and refers to the Human Epidermal Growth Factor Receptor 2 also known as Neu, ErbB-2, CD340 (cluster of differentiation 340) or p185. Amplification or over-expression of this gene has been shown to play an important ro...