To summarize the treatment strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive disease and triple-negative breast cancer (TNBC) who have residual disease after preoperative systemic therapy.#There has been a shift towards neoadjuvant systemic therapy for selected patients...
HEQA HEQAC HEQC HEQCO HEQE HEQEC HEQF HEQMPA HER HER1 HER2 HER4 HERA HERAC HERACLES HERALD HERALDS HERAP HERB HERBB HERBIE HERC HERCO HERCP HERCULAN HERCULES HERD HERDA HERDC HERDET HERDIN HERDS HERDSA HERDU HERE HEREC ▼
ER+ and HER2/neu-positive subtype ER+ and HER2/neu-negative subtype Basal-like breast cancer Breast cancer diagnosis A diagnostic delay, or the time between when you first notice symptoms and when you are diagnosed with breast cancer, determines how quickly you’re treated. The longer it takes...
What is triple negative breast cancer? Triple negative breast cancer (TNBC) means that the cancer cells do not have estrogen (ER) and progesterone (PR) on their surface, and they do not over-express the HER2 protein as well (HER2−). In contrast to TNBC, triple positive breast cancer ...
Triple-negative (ER-negative, PR-negative, HER2/neu not overexpressed) breast cancer has distinct clinical and pathologic features, and is a clinical probl... WJ Irvin,LA Carey - 《European Journal of Cancer》 被引量: 387发表: 2008年 Triple negative breast cancer: unmet medical needs Triple ...
Immunostudies for cytokeratin (CK) 7, CK20, estrogen receptor, progesterone receptor, HER2 NEU and thyroid transcription factor-1 were negative, indicating that breast, lung, pancreatic and biliary tree metastases were unlikely. Immunoperoxidase studies were positive for CK5/6, epithelial membrane ...
Abstract. Herceptin® (trastuzumab), an anti-HER2 monoclonal antibody, is the first oncogene-targeted therapy to be developed for the treatment of
HER2: Abbreviation forhuman epidermal growth factor receptor 2. HER2 is a transmembrane tyrosine kinase receptor and is expressed by, and involved in the growth of, some cancer cells. What does q2h mean in medical terms? q.2.h., q2h.every 2 hours. ...
Breastcancer Basal-like Triplenegative Prognosis Molecularprofiling Chemotherapy ABSTRACT Triple-negative(ER-negative,PR-negative,HER2/neunotoverexpressed)breastcancerhas distinctclinicalandpathologicfeatures,andisaclinicalproblembecauseofitsrelatively poorprognosis,aggressivebehaviourandlackoftargetedtherapies,leavingche...
The discordance rate in triple negative breast cancers has been shown to be 17.6%. That means 17.6% of triple negative breast cancers transform to Her2 positive status. Brufsky et al4 have shown that almost 33% of Her2 positive breast cancers have had CNS metastasis. Triple negative breast ...