Currently, the human epidermal growth factor receptor 2 (HER2) status of breast cancer is classified dichotomously as negative or positive to select patients for HER2-targeted therapy. However, with the introduction of novel treatment options, it is important to get more insight in the biology of...
Currently, the human epidermal growth factor receptor 2 (HER2) status of breast cancer is classified dichotomously as negative or positive to select patients for HER2-targeted therapy. However, with the introduction of novel treatment options, it is important to get more insight in the biology of...
Samples with scores of 0 and 1 + were considered HER2 negative, whereas samples with an IHC score of 3 + were classified as positive. Patients with a score of 2 + were considered “equivocal” for HER2 overexpression. Therefore, we conducted FISH for HER2 2 + cases, ...
HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal t
HER2-targeted therapies for patients with HER2+ breast cancer are rapidly evolving, offering a range of more complex and personalized treatment options. Currently, an array of anti-HER2 monoclonal antibodies, tyrosine kinase inhibitors and antibody–drug
The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug — the monoclonal
The various genomic elements and regions display disparities in substitution rates, their probability of being neutral or strongly linked to loci under selection, and their modes of inheritance, each of which is pertinent to the construction of phylogenomic trees. The benefits and drawbacks of each ...
CD10/CALLA (Neutral Endopeptidase) CD10抗原进口/国产 规格: 0.5mg ZCWCC1(Zinc finger CW-type coiled-coil domain protein 1) ZCWCC1抗原 现货供应 规格: 0.5mg CD105/Endoglin/TGF- Beta receptor CD105/转化生长因子β受体抗原特价促销 规格: 0.5mg ...
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Author details 1Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Cologne, Germany. 2Institute of Pathology, University Hospital Cologne, ...
Additional information Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary information Supplementary Information Peer Review File Description of Additional Supplementary Files Supplementary Data 1 Supplementary Data 2 ...