Her2/neu serum concentrations among the different groups of patients (i.e., healthy controls, USC 3 þ , USC 2 þ and USC 1 þ /negative) were summarised as means and compared with Student's t-test. Statistical analysis was performed using PASW version 18 (SPSS, Chicago, IL, USA)...
Expression of HER2/neu has also been reported to be a negative prognostic factor in a small survey of NT tumors. Here, we have investigated HER2/neu expression in 14 human and 2 murine neuroblastoma (NB) cell lines by flow cytometric analysis and in 93 NT by means of a certified ...
IHC 1+:HER2-negative IHC 0:HER2-negative Results usually show that a tumor is clearly HER2-positive or HER2-negative. If the test does not show a clear result, a report may indicate that a result is “equivocal.” Follow-up testing after an equivocal result may be performed on the same...
No significant differences in mCRP expression for CD46, CD55 and CD59 were detected when USC cell lines with high HER2/neu expression (i.e., FISH positive) were compared with those with low HER2/neu expression (i.e., FISH negative, data not shown). siRNA by 92% in USPC-ARK-2 and ...
Main Outcome Measures HER2/neu protein expression and HER2/neu gene amplification detected by means of IHC assessment and FISH, respectively. Results With IHC assessment, 10 cases showed overexpression (grade 3+) of HER2/neu protein, whereas 3 cases were negative for this protein (grade 0/1+)...
Data are displayed as CV of the 2500 means per fixed number of cells or FOVs, respectively. Agreement between the ECD/ICD ratio generated by image analysis and the pathologist's (F.F.) assessment for loss of ECD (positive, intermediate, or negative) was visualized using box plots. Cohen'...
We are conducting a Phase II clinical trial of the HER2 peptide vaccine AE37+GM-CSF for prevention of breast cancer recurrence in disease-free, node-positive or high-risk node-negative patients, who have completed standard of care therapy. AE37, an Ii-Key hybrid of the HER2/neuderived pept...
The same line was unable to recognize the HLA-DR+, HER- 2/neu negative(–) FM3 melanoma cell line. However, it prolifer- ated strongly upon stimulation with HER-2/neu-transfected FM3 cells (FM3/HER) and this response was also substantially blocked in the presence of the anti-HLA-DR...
Evaluation of Her-2/neu status in carcinomas with amplified chromosome 17 centromere locus. Am J Clin Pathol 2006;126:709–716. 35. Garcia-Pedrero JM, Kiskinis E, Parker MG, et al. The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in ...
Due to the tumor-restricted expression of NKG2DL, NKG2D-Fc-ADCC may constitute an attractive means for immunotherapy especially of HER2/neu-low or -negative breast cancer. 展开 DOI: 10.4049/jimmunol.1400872 被引量: 7 年份: 2014 收藏 引用 批量引用 报错 分享 ...