D. Chougale et al., "Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma," Biochemical and Biophysi- cal Research Communications, vol. 419, no. 3, pp. 490-494, 2012.A.M. Korwar, H.S. Bhonsle, A.D. Chougale, S.S. Kote, K.R. ...
aReproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age. 女性荷尔蒙感受器官正面,三倍消极和HER2-neu overexpressing的乳腺癌的再生因素和风险在妇女之中20-44岁。[translate]...
Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cellsGeradts J., Leek R Harris A L Wilson K S
elicited bystander activity, as demonstrated by reduction of MCF7 cell number. Lack of direct activity of ADCs on target-negative MCF7 cells was confirmed by treatment in the absence of SK-BR-3 cells. These data validate that the disulfide linker and cell permeability of PBD-monoamide enable ...
Thus, scores 0 and 1+ are considered negative, and score 3+, meaning that >30% of invasive tumour cells demonstrate uniform intense membrane staining, considered to be positive. An equivocal result represented by score 2+, requires further tests for confirming the presence or absence of HER2 ...
(Supplementary Fig.1). Like trastuzumab and pertuzumab21, hu 7C2 does not bind rodent neu (Supplementary Fig.1). FACS analysis in HER2+ BC cells demonstrates full binding of 7C2 in the presence of trastuzumab, pertuzumab or the combination (Supplementary Fig.2). Humanized 7C2 was ...
these cells. No detectable binding of MNP-HC was observed on HER2-negative MDA-MB-468 cells, unless using much higher doses (Supplementary Table1). Binding specificity was attributed to the antibody-derived half chains coupled to the nanoparticle surface, as demonstrated by comparison with IgG-...
HER2/neu is amplified and expressed in many human cancers, largely adenocarcinomas of breast, ovary, colon, and lung. In breast cancer, HER2/neu over-expression is associated with aggressive disease and is an independent predictor of poor prognosis. The HER2 protein is intimately associated with ...
As used herein the term “HER2” has its general meaning in the art and refers to the Human Epidermal Growth Factor Receptor 2 also known as Neu, ErbB-2, CD340 (cluster of differentiation 340) or p185. Amplification or over-expression of this gene has been shown to play an important ro...
(2007). Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basal-like breast carcinomas). Mod Pathol 20: 1200-1207.Lerma E, Peiro G, Ramon T et al (2007) Immunohistochemical heterogeneity of breast carcinomas negative for ...