A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming...
Summary Treatment of HER2 positive breast cancer is one of the great successes in recent breast oncology. This article will review recent information on patient and tumor selection for anti-HER2 therapy, and new data on optimal use of trastuzumab-based treatments in the adjuvant setting....
of sensitive cases HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive casesHER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of ...
A biopsy can tell whether the breast cancer has receptors for estrogen (ER-positive) and/or progesterone (PR-positive), indicating which hormone stimulates tumor growth. About two-thirds of breast cancers are hormone receptor-positive. Medications can be given that act to help prevent growth of ...
Breast cancer is one of the major causes of cancer-related morbidity and mortality in women worldwide. During the past three decades, several improvements in the adjuvant treatment of hormone receptor-positive/HER2−negative breast cancer have been achieved with the introduction of optimized adjuvant...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook Herceptin Medical Wikipedia Related to Herceptin:HER2 Her·cep·tin (hər-sĕp′tn) A trademark for the drug trastuzumab. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright ©...
Biopsy Results: HER2-Positive Breast Cancer HER-2 (human epidermal growth factor receptor 2) is a protein that is expressed at a high level by about 20% of breast cancers. Having this receptor means the cancer tends to grow and spread faster than other forms of breast cancer. However, ther...
2024 The former supermodel said in a new interview with The Australian Women’s Weekly that she was diagnosed with a type of breast cancer called HER2-positive estrogen-receptive intraductal carcinoma seven years ago. Maggie O'Neill, Health, 18 Sep. 2024 Though a vast majority of people knew...
The meaning of UNRESECTABLE is not capable of being surgically removed : not resectable. How to use unresectable in a sentence.
HER2 breast cancers tend to be aggressive, growing and spreading more quickly than hormone-receptor positive cancers, but they also are highly responsive to treatment. About one-quarter of breast cancers are HER2 positive. Rare forms of breast cancer include Paget disease and inflammatory carcinoma....