We found the article HER-2/neu expression in extramammary Paget disease: a clinicopathologic and immunohistochemistry (IHC) study of 47 cases with and without underlying malignancy very interesting. However, we were surprised to see that the authors interpreted all cases with a 2+ score on IHG ...
HER-2/neu status of the primary breast cancer (PBC) is determined by immunohistochemistry and fluorescent in situ hybridization. Because of a variety of technical factors, however, the PBC may not accurately reflect the metastatic tumor in terms of HER-2/neu status. Recently published guidelines ...
乳腺癌her检测专题知识 HER2基因 ➢HER2，又名HER2/neu，c-erbB-2，表皮生长因子受体（EGFR）家族组员；➢原癌基因，位于17q21，编码相对分子量185KD旳跨膜糖蛋白（跨膜酪氨酸激酶受体，表皮生长因子样分子），在细胞表面体现；➢经过参加信号传道通路旳一系列活动影响细胞旳增殖与分化。HER2受体跨膜二聚体旳...
All primary ileal NEN showed an intense membranous and cytoplasmic immunostaining for HER-2/neu. According to the breast cancer scoring system, 17% of ileal carcinoids showed a score of 3+ and 71% with a score of 2+ with a significant difference respect the non-ileal GEP endocrine tumors ...
曲妥珠单抗联合奥沙利铂,5-氟尿嘧 啶治疗 HER-2/neu 高表达晚期胃癌的临床疗效观察. 疑难病杂 志, 2013, 12(12): 930-932. 12 Qiu MZ, Li Q, Wang ZQ, et al. HER2-positive patients receiving trastuzumab treatment have a comparable prognosis with HER2- negative advanced gastric cancer patients:...
P5-11-15: Should HER-2 Score 0/1+ Breast Cancer Cases Be Retested by In-Situ Hybridisation? Results of a Multicenter Retesting Study.Background: HER-2 status is vital for selection of appropriate therapy for breast cancer patients... AM Reiner-Concin,S Lax,P Regitnig,... - 《Cancer ...
2/c ‑ neu)、her3(erbb ‑ 3)和her4(erbb ‑ 4)。 3.egfr存在于细胞表面上并且通过它的特异性配体的结合而被活化,该特异性配体包括表皮生长因子与转形生长因子α(tgfα)。当通过它的生长因子配体的活化后,该受体经受从无活性的主要单体形式至有活性的同型二聚体的转变。除了在配体结合以后形成同型...
Human epidermal growth factor receptor 2 (HER2) and HER3 form a potent pro-oncogenic heterocomplex1,2,3 upon binding of growth factor neuregulin-1β (NRG1β). The mechanism by which HER2 and HER3 interact remains unknown in the absence of any structures of the complex. Here we isolated ...
例如,我们所熟悉勺ER、PR和 erbB-2有足够的证据证明可以用于常规的临床预测HER2表达水平都成了判断预后的重要分子标志物, 预后指标。但随后专家们又意识到,有些肿瘤标志 同时也是内分泌治疗和针对HER2表达的靶向治疗 物可能不仅仅是预后指标,可能也是预测某种特定 的基础。甚至mdm2/p53通路上的基因,如eyelin 治疗...
(FISH), respectively, in hysterectomy specimens from 51 patients with uterine carcinosarcoma.RESULTS Her-2 protein expression in the epithelial component was negative in 42 patients (score 0 in 33 cases, score (+1) in 9 cases), score (+2) in 7 patients and score (+3) in 2 patients....