[6]Schmidt G, Gerlinger C, Juhasz-Böss I, et al. Her2-neu score as a prognostic factor for outcome in patients with triple-negative breast cancer. J Cancer Res Clin Oncol. 2016 Jun;142(6):1369-76. [7]Xu H, Han Y, W...
非曲妥珠单抗组患者的DFS显著低于曲妥珠单抗联合化疗组(倾向调整后的HR=3.29;P=0.026),以及曲妥珠单抗单药治疗组(倾向调整后的HR:2.15;P=0.012)。 同时,非曲妥珠单抗组局部复发较多,共有3例患者复发,其中1例为未接受放疗的同侧乳房...
Her2-neu score as a prognostic factor for outcome in patients with triple-negative breast cancer. J Cancer Res Clin Oncol. 2016;142(6):1369-76.Schmidt G, Gerlinger C, Juhasz-Boss I, Stickeler E, Rody A, Liedtke C, Wimberger P, Link T, Muller E, Fehm T, Abel M, Stein S, Bohle...
HER2的标准化检测 乳腺癌HER2的标准化检测 HER2基因 HER2，又名HER2/neu，c-erbB-2，表皮生长因子受体（EGFR）家族成员；原癌基因，位于17q21，编码相对分子量185KD的跨膜糖蛋白（跨膜酪氨酸激酶受体，表皮生长因子样分子），在细胞表面表达；通过参与信号传道通路的一系列活动影响细胞的增殖与分化。HER2...
胃癌Her2的检测--南京军区总医院周晓军主任 胃癌HER2的标准化检测 周晓军南京军区南京总医院 HER2基因 HER2，又名HER2/neu，c-erbB-2，表皮生长因子受体（EGFR）家族成员；原癌基因，位于17q21，编码相对分子量185KD的跨膜糖蛋白（跨膜酪氨酸激酶受体，表皮生长因子样分子），在细胞表面表达；通过参与信号...
點數呢D悶野留返比醫生,你知佢點匯報得喇。一般佢會比一個叫c-erbB2 score你,有D報告寫HER2/neu,其實都係講同一樣野。佢有4個可能性:0,1+,2+,3+。呢度好多病友搞錯以為「+就等如陽性、等如係HER2型」,呢個係錯嘅。你可以睇成+代表有天線,數字先反影有幾多天線。最終就會係咁: ...
曲妥珠单抗/HER2(PDB代码1N8Z)复合物和帕妥珠单抗/HER2复合物(PDB代码1S78)的结构用于建模。可采用分子动力学(MD)评价WT复合物在水环境中的内在动态性质。平均场和死端排除法连同柔性骨架可用于优化和制备待筛选突变体的模型结构。包装后将为许多特征评分,包括接触密度、碰撞得分(clashscore)、疏水性和静电。一般...
The HER2 gene (also known as HER2/neu, c-erbB-2) is located at 17q12 and is a member of the epidermal growth factor receptor (HER) family, which plays an important regulatory role in cellular physiological processes. The Luminal B BRCA subtype is characterized by its highly proliferative, ...
d, HER2-S310F/HER3 model colored by estimated Q-score with the same scale as in b. Expected Q-score for 3.1Å structure is 0.569. e, Overlay of the HER2/HER3/NRG1β heterocomplexes with symmetric structures of EGFR/EGF (PDB ID 3NJP), EGFR/TGFα (PDB ID 1MOX) and HER4/NRG1...
The HER2low category represents tumors with an IHC score of 1 + or 2 + without amplification. According to this definition, HER2- only includes those patients with an IHC score of 0. In HER2low breast cancer cases, the number of receptors is low compared to cases with HER2 amplif...