其中,人表皮生长因子受体2 (HER2) 是乳腺癌中一种非常重要的生物标志物[2],约20%的乳腺癌患者HER2高表达(HER2+),此类患者对于靶向治疗敏感。 对于早期HER2+乳腺癌,术后辅助靶向治疗联合化疗可以显著延长患者的无复发生存期,是此类...
[7] Lambein K, Van Bockstal M, Vandemaele L, et al. Distinguishing score 0 from score 1+ in HER2 immunohistochemistry-negative breast cancer: clinical and pathobiological relevance. Am J Clin Pathol. 2013 Oct;140(4)...
In the normal oral mucosa, one case was positive (Score 2) with HER2/neu but αSMA positive myofibroblasts were not seen in the stroma of OSCC. A significant difference was seen in αSMA expression in OSCC and the normal oral mucosa ( p =0.002). No significant difference was found in ...
Her-2/neu基因的蛋白 CerbB-2 ● 癌细胞表面存在着CerbB-2蛋白, 受刺激后促进癌细胞的增殖 刺激 増殖 がん細胞 ● 20～30%的癌细胞 Heceptin:一种针对Her-2/neu 受体的高纯度重组DNA衍生物的人源化 单克隆抗体,是乳腺癌治疗领域的第一 个分子靶向性药物,具有高效、低毒、 选择性强的特点 ●与CerbB-...
點數呢D悶野留返比醫生,你知佢點匯報得喇。一般佢會比一個叫c-erbB2 score你,有D報告寫HER2/neu,其實都係講同一樣野。佢有4個可能性:0,1+,2+,3+。呢度好多病友搞錯以為「+就等如陽性、等如係HER2型」,呢個係錯嘅。你可以睇成+代表有天線,數字先反影有幾多天線。最終就會係咁: ...
HER2本文描述的抗原结合构建体具有与HER2的ECD2和ECD4结合的抗原结合多肽构建体。措辞“ErbB2”和“HER2”在本文中可交换使用并且是指,例如在Semba等,PNAS(USA)82:6497-6501(1985)和Yamamoto等Nature319:230-234(1986)中描述的人HER2蛋白(基因库登录号X03363)。术语“erbB2”和“neu”是指编码人ErbB2蛋白的...
User feedback (n = 105) revealed a mean SUS score of 73.16, signifying a positive user experience. A high degree of overall acceptability was noted, with the UTAUT2 factors ordered from greatest to least significance: Price Value, Performance Expectancy, Social Influence, and Facilitating ...
J. et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707–712 (1989). Article CAS PubMed Google Scholar Swain, S. M., Shastry, M. & Hamilton, E. Targeting HER2-positive breast cancer: advances and future directions. Nat. Rev. Drug. ...
In the normal oral mucosa, one case was positive (Score 2) with HER2/neu but αSMA positive myofibroblasts were not seen in the stroma of OSCC. A significant difference was seen in αSMA expression in OSCC and the normal oral mucosa ( p =0.002). No significant difference was found in ...
The HER2 gene (also known as HER2/neu, c-erbB-2) is located at 17q12 and is a member of the epidermal growth factor receptor (HER) family, which plays an important regulatory role in cellular physiological processes. The Luminal B BRCA subtype is characterized by its highly proliferative, ...