2. Slamon, Dennis J., et al. "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene." science 235.4785 (1987): 177-182. 3. Slamon, Dennis, et al. "Adjuvant tras...
[6]Schmidt G, Gerlinger C, Juhasz-Böss I, et al. Her2-neu score as a prognostic factor for outcome in patients with triple-negative breast cancer. J Cancer Res Clin Oncol. 2016 Jun;142(6):1369-76. [7]Xu H, Han Y, W...
score 3+ was found in eight cases also by both methods. discussion: the most common method used in routine clinical practice to determine her-2/neu status is immunohistochemistry. variability of her-2/neu results can be caused by a number of variables including time of fixation, methods of ...
HER2的标准化检测 乳腺癌HER2的标准化检测 HER2基因 HER2，又名HER2/neu，c-erbB-2，表皮生长因子受体（EGFR）家族成员；原癌基因，位于17q21，编码相对分子量185KD的跨膜糖蛋白（跨膜酪氨酸激酶受体，表皮生长因子样分子），在细胞表面表达；通过参与信号传道通路的一系列活动影响细胞的增殖与分化。HER2...
J. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177–182 (1987). Article CAS PubMed Google Scholar Chang, J. C. HER2 inhibition: from discovery to clinical practice. Clin. Cancer Res. 13, 1–3 (2007). ...
p185或p185neu是指neu基因的蛋白质产物。HER2为HER受体。“HER受体”是属于人表皮生长因子受体(HER)家族的受体蛋白酪氨酸激酶并且包括EGFR、HER2、HER3和HER4受体。HER受体通常将包含可结合HER配体的胞外结构域;亲脂性跨膜结构域;保守性胞内酪氨酸激酶结构域;和带有几个可以磷酸化的酪氨酸残基的羧基端信号传导...
HER2，又名HER2/neu，c-erbB-2，表皮生长因子受体（EGFR）家族成员；原癌基因，位于17q21，编码相对分子量185KD的跨膜糖蛋白（跨膜酪氨酸激酶受体，表皮生长因子样分子），在细胞表面表达；通过参与信号传道通路的一系列活动影响细胞的增殖与分化。HER2受体跨膜二聚体的信号传导途径 生长因子（配体）接合...
The HER2 gene (also known as HER2/neu, c-erbB-2) is located at 17q12 and is a member of the epidermal growth factor receptor (HER) family, which plays an important regulatory role in cellular physiological processes. The Luminal B BRCA subtype is characterized by its highly proliferative, ...
點數呢D悶野留返比醫生,你知佢點匯報得喇。一般佢會比一個叫c-erbB2 score你,有D報告寫HER2/neu,其實都係講同一樣野。佢有4個可能性:0,1+,2+,3+。呢度好多病友搞錯以為「+就等如陽性、等如係HER2型」,呢個係錯嘅。你可以睇成+代表有天線,數字先反影有幾多天線。最終就會係咁: ...
Scores 0 and 1+ display negative HER2 status, and score 3+ indicates positive HER2 status. Score 2+ has to be analyzed further by fluorescence or chromogenic in situ hybridization (see Fig. 1). The evaluation of immunohistochemical expression was assessed manually by two pathologists (A.Q. ...