[6]Schmidt G, Gerlinger C, Juhasz-Böss I, et al. Her2-neu score as a prognostic factor for outcome in patients with triple-negative breast cancer. J Cancer Res Clin Oncol. 2016 Jun;142(6):1369-76. [7]Xu H, Han Y, W...
2. Slamon, Dennis J., et al. "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene." science 235.4785 (1987): 177-182. 3. Slamon, Dennis, et al. "Adjuvant tras...
Particularly, the impact of Her2-neu score 0 versus Her2-neu score 1 and 2 on survival was investigated. Materials and methods: We retrospectively studied a cohort of 1013 patients with TNBC, diagnosed at seven hospitals between May 2002 and February 2015. We studied the impact of Her2-neu ...
J. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177–182 (1987). Article CAS PubMed Google Scholar Chang, J. C. HER2 inhibition: from discovery to clinical practice. Clin. Cancer Res. 13, 1–3 (2007). ...
H-score=1×"低"比例+2×"中"比例+3×"高"比例。仅1/9患者(MGH009)H-score差异>1(复发时表达升高)。(C)代表性图像显示治疗前与复发匹配CTC的TROP2表达及细胞形态学特征(包括CTC簇形成)无变化。(D)7例患者治疗前与进展时CTC的HER2表达分布条形图(含20mL标准化CTC数量及时间点)。(E)散点图展示7例患者...
點數呢D悶野留返比醫生,你知佢點匯報得喇。一般佢會比一個叫c-erbB2 score你,有D報告寫HER2/neu,其實都係講同一樣野。佢有4個可能性:0,1+,2+,3+。呢度好多病友搞錯以為「+就等如陽性、等如係HER2型」,呢個係錯嘅。你可以睇成+代表有天線,數字先反影有幾多天線。最終就會係咁: ...
Her-2/neu基因的蛋白 CerbB-2 ● 癌细胞表面存在着CerbB-2蛋白, 受刺激后促进癌细胞的增殖 刺激 増殖 がん細胞 ● 20～30%的癌细胞 Heceptin:一种针对Her-2/neu 受体的高纯度重组DNA衍生物的人源化 单克隆抗体,是乳腺癌治疗领域的第一 个分子靶向性药物,具有高效、低毒、 选择性强的特点 ●与CerbB-...
HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma Mod Pathol, 24 (2011), pp. 899-907 10.1038/modpathol.2011.47 PubMed PMID: 21460800; PMCID 3138485 View PDFView articleCrossrefView in ScopusGoogle Scholar 70 RE Roses, EC Paulson, A Sharma HER-2/neu overexpression...
HER2/Neu, a member of the ErbB family of receptor tyrosine kinases (RTKs), has received considerable attention as a promising therapeutic target for various cancers, including GC3. Typically, HER2 overexpression by 10–25% in GC is associated with a poor prognosis4. Trastuzumab is a targeted ...
p185或p185neu是指neu基因的蛋白质产物。HER2为HER受体。“HER受体”是属于人表皮生长因子受体(HER)家族的受体蛋白酪氨酸激酶并且包括EGFR、HER2、HER3和HER4受体。HER受体通常将包含可结合HER配体的胞外结构域;亲脂性跨膜结构域;保守性胞内酪氨酸激酶结构域;和带有几个可以磷酸化的酪氨酸残基的羧基端信号传导...