DNA RepairSidorova JM. Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst.) 2008; 7 :1776–1786.J.M. Sidorova, Roles of the Werner syndrome RecQ helicase in DNA replication, DNA Repair (Amst.) 7 (2008) 1776-1786....
Helicase is one of the proteins that regulate DNA replication.Helicase Definition Several proteins, or enzymes, in the cell are responsible for cell function such as the enzyme DNA helicase. A cell's structure and biochemical integrity is dictated by a coding software just as it is found in a...
Specialized DNA helicases efficiently unwind G-quadruplex (G4) DNA and other forms of alternative DNA structures such as telomeric displacement loops (T-loops). Emerging evidence suggests that DNA helicases that unwind non-conventional DNA structures have important roles in the replication or repair ...
Specialized DNA helicases efficiently unwind G-quadruplex (G4) DNA and other forms of alternative DNA structures such as telomeric displacement loops (T-loops). Emerging evidence suggests that DNA helicases that unwind non-conventional DNA structures have important roles in the replication or repair ...
A functional characterisation of the DNA helicase Ch1R1 in DNA replication and repair ChlR1 is a DNA helicase implicated in diverse cellular processes including sister chromatid cohesion and DNA replication and repair. However, the mechanism by which ChlR1 participates in these processes is unknown. ...
What do single-stranded binding proteins do in DNA replication? What substrate does DNA helicase work on? Is DNA-binding protein FIS a transcriptional activator? What type of biological molecule is DNA helicase? What does DNA polymerase bind to?
RECQ1-deficient MMCs show spontaneous DNA breaks and activate the DNA damage response (DDR) Given the known role of RECQ1 in DNA replication and DDR,21,47 the effect of RECQ1 depletion on spontaneous DNA damage was investigated. Interestingly, RECQ1 depletion in XG19 HMCLs induced DNA strand...
The replicative helicase unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. In eukaryotes, the replicative helicase is composed of the Cdc45 protein, the heterohexameric ring-shaped Mcm2-7 complex, and the tetrameric ...
What is the function of Z-DNA? What substrate does DNA helicase work on? What is the function of topoisomerase in DNA replication? What is the function of polymerase 3? What is the function of DNA ligase in genetic engineering? What is the function of DNA gyrase?
Cellular and biochemical studies support a role for all five human RecQ helicases in DNA replication; however, their specific functions during this process are unclear. Here we investigate the in vivo association of the five human RecQ helicases with three well-characterized human replication origins...