The main function of DNA helicase is unwinding nucleic acids using ATP driven motor force in several cellular processes involving DNA replication,... Learn more about this topic: DNA Helicase | Overview, Definition & Function from Chapter 11/ Lesson 6 ...
To elucidate the precise function of RecQ helicase in DNA repair and replication aims not only to improve our understanding of the molecular basis for tumorigenesis, but also to extend the range of potential therapeutic targets.Hideo Kaneko and Toshiyuki Fukao and Naomi KondoAdvances in Biophysics...
Helicase Function Helicase performs a variety of functions in the cell. Its most prominent task is to break hydrogen bonds between nitrogen containing bases (nucleobases). This occurs during the beginning of DNA replication. If DNA isn't unzipped, it will not be able to replicate. Helicase can...
Describe the function of DNA polymerase II in leading strand synthesis in DNA synthesis. Describe the role of DNA polymerase: Explain the functions of all enzymes involved in the replication of DNA. Describe the function of helicase in opening the helix in DNA synthesis. ...
Question: Helicases are ubiquitous enzymes vital to all living organisms. They are involved in various aspects of cellular processes including DNA repair, recombination, replication, transcription and RNA processing. Helicases are motor proteins that move directionally along the nucleic acid phosphodiester...
Mutations in human homologues of the bacterial RecQ helicase cause diseases leading to cancer predisposition and/or shortened lifespan (Werner, Bloom, and RothmundThomson syndromes). The budding yeast Saccharomyces cerevisiae has one RecQ helicase, Sgs1, which functions with Top3 and Rmi1 in DNA re...
Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression Little is known about the DNA helicases required for the elongation phase of eukaryotic chromosome replication. Minichromosome maintenance (MCM) protein co... Labib,K. - 《Science》 被引量: 1271发表: 2000年 Erratum: ...
Structure and Function of RecQ DNA Helicases, Critical Reviews in Biochemistry and Molecular Biology, Informa Healthcare RecQ family helicases play important roles in coordinating genome maintenance pathways in living cells. In the absence of functional RecQ proteins, cells e... RJ Bennett,JL Keck ...
Many helicases unwind G4 structures and preserve genome stability, but a detailed understanding of G4 replication and the re-start of stalled replication forks around formed G4 structures is not clear, yet. In our recent study, we identified that Mgs1 preferentially binds to G4 DNA structures...
Notably, cells need error-free bypass pathways and homologous recombination to deal with DNA lesions that arise when the helicase function of Rrm3 is disrupted, but not when its replication function is disrupted. This indicates that the DNA lesions that form in the absence of the two distinct ...