The main function of DNA helicase is unwinding nucleic acids using ATP driven motor force in several cellular processes involving DNA replication,... Learn more about this topic: DNA Helicase | Overview, Definition & Function from Chapter 11/ Lesson 6 ...
Helicase Function Helicase performs a variety of functions in the cell. Its most prominent task is to break hydrogen bonds between nitrogen containing bases (nucleobases). This occurs during the beginning of DNA replication. If DNA isn't unzipped, it will not be able to replicate. Helicase can...
Describe the function of DNA polymerase II in leading strand synthesis in DNA synthesis. Describe the role of DNA polymerase: Explain the functions of all enzymes involved in the replication of DNA. Describe the function of helicase in opening the helix in DNA synthesis. ...
In the latter of the review, the functional domains of BLM, those are nuclear localization signal and the interacting proteins such as ATM, are shown. Several lines of reports indicates that BLM helicase is involved in the re-initiation of DNA replication at sites where replication forks have ...
Question: Helicases are ubiquitous enzymes vital to all living organisms. They are involved in various aspects of cellular processes including DNA repair, recombination, replication, transcription and RNA processing. Helicases are motor proteins that move directionally along the nucleic acid phosphodiester...
None of these enzymes possesses a proofreading subdomain, and their intrinsic fidelity of DNA synthesis is much lower than that of a polymerase that functions in cellular DNA replication. In this review, we discuss the similarities and differences of three members of Family X: polymerases β, ...
Erratum: Uninterrupted MCM2-7 function required for DNA replication fork progression (Science (2 June) (1643)) Little is known about the DNA helicases required for the elongation phase of eukaryotic chromosome replication. Minichromosome maintenance (MCM) protein co... K Labib 被引量: 791发表:...
DNA polymerase ε (Polε) is thought to be involved in DNA replication, repair, and cell-cycle checkpoint control in eukaryotic cells. Although the require... S Waga,T Masuda,H Takisawa,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 89...
Many helicases unwind G4 structures and preserve genome stability, but a detailed understanding of G4 replication and the re-start of stalled replication forks around formed G4 structures is not clear, yet. In our recent study, we identified that Mgs1 preferentially binds to G4 DNA structures...
What Does DNA Ligase Do? DNA Ligase in Genetic Engineering Lesson Summary Frequently Asked Questions What is the action of DNA ligase in DNA replication? DNA ligase fuses together Okazaki fragments on the lagging strand during replication. It does this by covalently linking the 3' hydroxyl group...