Despite extensive studies on DNA replication, the exchange mechanisms of DNA polymerase during replication remain unclear. Existing models propose that this exchange is facilitated by protein partners like helicase. Here we present data, employing a comb
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefore it is tightly controlled and coordinated with processes that maintain genomic stability. Human RecQ helicases are among the most important factors involved in the maintenance of replication fork integrity...
State whether the following statement is true or false: DNA replication is a conservative process. The term "semi-conservative" when used to describe DNA replication refers to: a. the fact that after DNA replication has occurred, each DNA con...
During DNA replication, CST disrupts the interaction of Chromatin licensing and DNA replication factor (CDT1) with the Minichromosome maintenance helicase complex (MCM) to limit replication origin firing and it interacts with AND1/Polα to promote replisome assembly42. Notably, CST also facilitates ...
Learn about DNA replication enzymes and how DNA replicates. Discover what enzymes are used in DNA replication, and the order of enzymes involved in DNA replication. Related to this Question What is made during DNA replication? What is accomplished by DNA replication?
After DNA replication is complete at the exit point of the S phase, removal of excess FEN1 may be crucial. Here, we report a mechanism that controls the programmed degradation of FEN1 via a sequential cascade of posttranslational modifications. We found that FEN1 phosphorylation stimulated its ...
The transcriptional machinery is thought to dissociate from DNA during replication. Certain proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands in order to maintain the memory of transcriptional states1,2. These pro
In eukaryotes, DNA replication is initiated at multiple individual replication origins, and its licensing involves recruitment of the origin recognition complex, multiple other proteins, and the loading of MCM2-7 helicase [13,14]. Together, these factors constitute pre-replicative complexes (pre-RCs)...
DNA replication errors have been implicated in the generation of a major class of CNVs, the nonrecurrent CNVs. We have found that agents that perturb ... MF Arlt,TE Wilson,TW Glover - 《Current Opinion in Genetics & Development》 被引量: 107发表: 2012年 Telomerase Is Essential to Alleviate...
The role of simian virus 40 (SV40) large tumor antigen (T antigen) as a DNA helicase at the replication fork was studied. We found that a T-antigen hexamer complex acts during the unidirectional unwinding of appropriate DNA substrates and is localized directly in the center of the fork, con...