The essential role of human RecQ helicases in the genome maintenance during DNA replication is underlined by association of defects in their function with cancer predispositionVaclav UrbanJana DobrovolnaPavel JanscakBiophysical ChemistryUrban, V.; Dobrovolna, J.; Janscak, P. Distinct functions of ...
Helicase Function Helicase performs a variety of functions in the cell. Its most prominent task is to break hydrogen bonds between nitrogen containing bases (nucleobases). This occurs during the beginning of DNA replication. If DNA isn't unzipped, it will not be able to replicate. Helicase can...
What is the function of DNA ligase in genetic engineering? What is the function of DNA gyrase? What does the action of helicase create? What is the primary function of DNA? What is the role of enzymes in DNA replication? What is the role of DNA polymerase during DNA synthesis?
Specialized DNA helicases efficiently unwind G-quadruplex (G4) DNA and other forms of alternative DNA structures such as telomeric displacement loops (T-loops). Emerging evidence suggests that DNA helicases that unwind non-conventional DNA structures have important roles in the replication or repair ...
Mechanistically, MCM8IP stimulates the helicase activity of MCM8-9. Collectively, our work identifies MCM8IP as a key regulator of MCM8-9-dependent DNA synthesis during DNA recombination and replication.Similar content being viewed by others HELQ is a dual-function DSB repair enzyme modulated by...
HumanUSP50lies head-to-head withUSP8on chromosome 15, and the USP50 protein sequence shares 36.6% identity with the C-terminal USP domain of USP8, leading us to consider whether USP8 has a similar function to USP50. Using spontaneous 53BP1 foci to indicate replication difficulties, we compared...
During DNA replication, forks often stall and require restart. One mechanism for restart requires that the fork be moved in a direction opposite to that of replication. This reaction is known as fork regression. For this reaction to occur, the enzyme must couple unwinding of the nascent hetero...
The RecQ helicases, which are essential for the maintenance of genome stability, are thought to function during DNA replication. In particular, RecQ helicase mutants display replication defects and have phenotypes consistent with an inability to efficiently reinitiate replication following replication fork...
What is the function of DNA helicase? During transcription of mRNA, is helicase needed to separate the two strands of the DNA double helix? Is DNA replication part of protein synthesis? Does DNA helicase cause positive supercoils? Is DNA polymerase a protein?
摘要: Explains the mechanism of termination of DNA replication in helicase-contrahelicase interactions. Imposition of polar barrier in RTP-terminus DNA interaction; Restriction of fork arrest to the replication terminus.被引量: 41 年份: 1996