(2007b). XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening . DNA Repair (Amst.) 6 , 157–16610.1016/j.dnarep.2007.02.007 [ Cross Ref ]Wu L. Role of the BLM helicase in replication fork management. DNA ...
Explain the role of DNA polymerases in replication. What are the role of DNA polymerase and RNA polymerase? What is the role of DNA polymerase III? How are the hydrogen bonds important in the replication of DNA? What is helicase? Describe its role in DNA replication. What role do single-...
Conclusions These data suggest that the PriA protein is needed for survival and persistence of H. pylori in mice stomach mucosa. 展开 关键词: Helicobacter pylori DNA helicase replication fork stabilization DOI: 10.1016/S0016-5085(14)61813-8 被引量: 1 ...
The active replicative helicase complex consists of Cdc45, the Mcm2–7 complex, and the GINS complex, and is called the CMG (Cdc45–Mcm2–7–GINS) complex. In the initiation reaction, many replication proteins assemble onto the Mcm2–7 complex to facilitate the formation of the CMG complex...
For replication, the DNA has to unwind and the two strands need to separate. These tasks are performed in cooperation by the topoisomerase and helicase enzymes. One of the most studied and thus best-understood helicase enzymes is that of the gram-positive bacterium named the plasmid copy-reduced...
It is clear from both genetic and biochemical studies that several subunits of the hexameric MCM2–7 DNA helicase/ATPase are substrates of DDK. In an allosteric model of DDK function, DDK phosphorylates the Mcm4 protein in the misaligned MCM2–7 double hexamer bound to origins of replication ...
Cells use an elaborate innate immune surveillance and defense system against virus infections. Here, we discuss recent studies that reveal how HIV-1 is sensed by the innate immune system. Furthermore, we present mechanisms on the counteraction of HIV-1.
The replicative helicase unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. In eukaryotes, the replicative helicase is composed of the Cdc45 protein, the heterohexameric ring-shaped Mcm2-7 complex, and the tetrameric ...
of proteins that occur in these diseases may be aggravated by oxidative damage, and may in turn cause more oxidative damage by interfering with the function of the proteasome. Indeed, it has been shown that proteasomal inhibition increases levels of oxidative damage not only to proteins but also...
DNA Replication:DNA replication is the process of formation of a new DNA strand from the parent strand by the use of certain enzymes such as polymerases, ligases, and topoisomerases. DNA replication takes place in the nucleus of the cell....