PDF 引用 收藏 摘要原文 Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged ...
Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the ident...
Next, we will focus on the different hallmarks of cellular senescence and cellular ageing, and the detection techniques most suitable for immune cells. Applying these techniques will deepen our understanding of immune cell senescence and to discover potential druggable pathways, which can be modulated ...
Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging. Sci. China Life Sci. 66, 2818–2836 (2023). Article CAS PubMed Google Scholar Deng, J. et al. miR-143-3p promotes ovarian granulosa cell senescence and inhibits ...
Faculty of 1000 evaluation for Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. P Kaldis 被引量: 0发表: 2010年 SIRT-associated attenuation of cellular senescence in vascular wall Cyril and Methodius University, Skopje 1000, North MacedoniaMilena Keremidarska...
falciparum, showing its highly unique composition carrying features of both cellular quiescence and senescence. We also demonstrate that the induced dormant forms require ~5 days of maturation, after which the resulting day 5 mature dormant persisters (d5MDP) exhibit resilience to a broad spectrum of...
View PDFView articleView in ScopusGoogle Scholar 98 W.E Wright, O.M Pereira-Smith, J.W Shay Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts Mol. Cell. Biol., 9 (1989), pp. 3088-3092 View in ScopusGoogle Scholar 99 A.H Wyllie, J.F Kerr...
这一版在原有的6大标志性特征的基础上增加了4个新的标志性特征,分别是:细胞能量代谢的失控(deregulating cellular energetics),逃避免疫清除(avoiding immune destruction),肿瘤促炎症作用(tumor-promoting inflammation),基因组的不稳定性和突变(genome instability and mutation),并将原有的6大标志性特征概念的内涵和...
Every tissue is exposed to insults that require cellular turnover through the activity of adult stem cells (ASCs). In recent years, it has become clear that strategies to support the maintenance of homeostasis and repair after damage differ widely across tissues. For decades, the hematopoietic sy...
hallmarks of cancer the next generation癌症前沿评论标志下一代2和robertaweinber.pdf,维持增殖信号 可以说,癌细胞最基本的特征涉及其维持慢性增殖的能力。正常组织仔细控制生长促进信号的产生和释放,这些信号指示进入细胞生长 和 周期并进行进展,从而确保细胞数量的稳