Provided is the use of a biomarker panel comprising six or more polypeptides, or their encoding mRNA's, wherein the panel comprises at least the biomarkers TSPAN13, GDNF, C2CD5, SUSD6, BCL2L2, PLK3, or a variant or fragment thereof, as a biomarker set for cellular senescence. Also ...
Cellular aging is defined as progressive loss of physiological integrity and thus, the driving intrinsic component of increased age-specific mortality6. There are several hallmarks of cellular aging including telomere length (TL), cellular senescence and telomerase activity7. Telomeres, the non-coding ...
英文关键词:AgingBiomarkersCellular senescenceHealth impact assessment 基金项目: 摘要点击次数:3606 全文下载次数:2552 中文摘要: 衰老是一种适应和受调控的过程,可能还伴随有害事件随机累积的结果,最终导致机体健康状况下降、患病风险增加和死亡。随着衰老的研究,衰老的部分意义被阐述,衰老的复杂特征轮廓渐明了。衰老的...
These works illustrated the impact on synaptogenesis and the role of SNCA-AS1 in cellular senescence and PD-related pathologies [104, 105]. Due to the overlap between α-syn, tau, and amyloid beta (Aβ) pathologies in DLB and PDD, an opportunity presents to compare genotypes with prognostic...
Cellular senescence is a state of stable growth arrest in response to stress, which is a fundamental process of biological aging. They secrete products, the Senescence-Associated Secretory Phenotype (SASP), which consists of inflammatory cytokines, chemokines, growth factors and matrix remodeling protein...
Hipkiss,Alan R - 《Expert Review of Neurotherapeutics》 被引量: 38发表: 2009年 A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence In contrast to other mouse models that are deficient in antioxidant enzym...
Hormetic Modulation of Aging in Human Cells An experimental model system that has been used in testing and applying hormesis as a modulator of aging is the so-called Hayflick system of cellular aging in vitro. In modern biogerontology, the terms "cellular aging", "cell senescence"... SIS Ratt...
as proteasomal protein catabolic processes (GO:0010498), proteasome-mediated ubiquitin-dependent protein catabolic processes (GO:0043161), mRNA processing (GO:0006397), positive regulation of cellular catabolic processes (GO:0031331), and the regulation of cellular protein catabolic processes (GO:1903362)...
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases Zeming Wu Jing Qu Guang-Hui Liu Nature Reviews Molecular Cell Biology(2024) Depletion of loss-of-function germline mutations in centenarians reveals longevity genes ...
Neuroblastoma is among the most common extracranial malignant solid tumours of childhood. Its clinical symptoms vary widely among children, with some tumours regressing on their own [87]. After low-dose chemotherapeutic drug stimulation induced cellular senescence of neuroblastoma cell lines, MICA release...