常用的GWAS summary data数据库汇总如下。 ✅GWAS Catalog(全称:Genome-Wide Association Study Catalog)是一个存储基因组范围关联研究(GWAS)结果的数据库。收集、整理和提供了各种研究中发现的基因-表型关联数据。其是EMBL-EBI旗下的一个数据库,收录了比较全的公开发表的GWAS分析结果。 该数据库提供了以下信息:关联...
Summary statistics from genome-wide association studies (GWAS) have facilitated the development of various summary data-based methods, which typically require a reference sample for linkage disequilibrium (LD) estimation. Analyses using these methods may be biased by errors in GWAS summary dataor LD ...
对于尚未被IEU GWAS database收录、但已上传至GWAS Catalog的GWAS结果,我们可以在GWAS Catalog下载GWAS Summary Results。 【注意】有时作者仅会在个人主页提供GWAS Summary Results下载链接,请见机行事。 以Demange et al.(2021;PMID:33414549)的论文为例,非认知能力(noncognitive ability)的GWAS结果尚未被IEU GWAS ...
",进入页面:https://www.ebi.ac.uk/gwas/downloads/summary-statistics,得到一个由三部分组成的界面 1)List of published studies with summary statistics:这里的GWAS研究都是已经发表的,质量有保证,你可以在检索框里输入关键词("First author", "Study accession", "Reported trait", "Trait(s)")进行筛选 2...
UKbiobank的GWAS summary数据:https://ctg.cncr.nl/documents/p1651/ukb2_sumstats.tar.gz 这个数据很大,下载请谨慎。 7、失眠、阿尔兹海默症、各种精神类疾病、智力等的summary数据库 https://ctg.cncr.nl/software/summary_statistics 8、日本的公共数据库National Bioscience Database Centre (NBDC) Human Data...
这些字段是染色体(染色体)、染色体上的基因组位置 (base_pair_location)、效应等位基因 (effect_allele) 和非效应等位基因 (other_allele)。染色体值是从 1 到 25 的整数,染色体 X 映射到 23,染色体 Y 映射到 24,线粒体映射到 25。基因组位置是一个整数值,代表变异在参考基因组中的第一个位置,使用基于1的...
Here are some example ‘structures’ of summary datasets that it should be able to handle Data structures - - Figure 2: Data structures + + Figure 2: Data structures - Note that the whole OpenGWAS database is an example of a ‘complete’ -dataset - all traits and all variants. What...
GWAS summary statistics of the 13 dietary habits investigated are publicly available at the National Bioscience Database Centre (NBDC) Human Database (Research ID: hum0014) as open data with no access restrictions. GWAS genotype data were deposited at the NBDC Human Database (Research ID: hum...
By combining GWAS summary statistics with scRNA-seq data, we found that cholangiocytes exhibited a notable enrichment by PBC-related genetic association signals (Permuted P < 0.05). The risk gene of ORMDL3 showed the highest expression proportion in cholangiocytes than other liver cells (22.38%...
Here we present the OpenGWAS database, an open source, open access, scalable and high-performance cloud-based data infrastructure that imports and publishes complete GWAS summary datasets and metadata for the scientific community. Our import pipeline harmonises these datasets against dbSNP and the ...