参考: 【1】Fongang B; Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium. A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimers Dement. 2024 Jul 24. doi: 10.1002/alz.14115. 【2】孟德尔随机化GWAS数据样本量不够怎么办?试试GWAS的Meta分析! (qq...
Vedantam S, Workalemahu T, Kilpeläinen TO, Scherag A, Esko T, Kutalik Z, Heid IM, Loos RJ; Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Quality control and conduct of genome-wide association
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol. Psychiatry 22, 336-345. doi: 10.1038/mp.2016.244Trampush, J., Yang, M., Yu, J., Knowles, E., Davies, G., Liewald, D., Starr, J., Djurovic, S.,...
✅PGC (Psychiatric Genomics Consortium)网站提供了抑郁症,双相情感障碍,精神分裂症等精神疾病的GWAS summary data,由多个机构合作完成了多个大样本量的GWAS meta分析。数据下载需注册账号。 网址:med.unc.edu/pgc/ ✅SSGAC (Social Science Genetic Association Consortium)提供了教育水平,经济和政治取向,人格等行为...
Genomics England Research Consortium Collaborators, Jenny Chambers, Argyro Syngelaki, Jennifer Donnelly, Sharon Cooley, Michael Geary, Kypros Nicolaides, Malin Thorsell, William M. Hague, Maria Cecilia Estiu, Hanns-Ulrich Marschall, Daniel P. Gale & Catherine Williamson Nature...
所以,科学家们推测missing heritability的其中几个原因。第一,有可能是现阶段GWAS的power还不够,不能发现效应更小的基因(根据Pritchard的Cell文章的泛基因性Omnigenic假说,这些基因可能是core gene,也可能是peripheral gene),根据这个推测,国际上又开始...
GWAS summary数据,即GWAS汇总关联统计数据,是由一个或多个来源的个体水平的GWAS数据经过meta分析而来,反映SNP对表型影响的相关信息。一个GWAS summary数据通常包括遗传变异标识、等位基因、效应大小及其标准差、P值、样本量等信息。 ꔷ CHR(chr):SNP位于的染色体编号 ...
这些发现与先前的结果一致,即偏头痛是几种心血管特征的危险因素,并且与血压具有遗传相关性。然而,研究者使用CARDIoGRAMplusCD4 Consortium(n=336,924)和UK Biobank(n=422,771)的高血压GWAS数据的最新meta分析没有观察到偏头痛和冠状动脉...
MR-MEGA 跨族裔GWAS荟萃分析 Meta-analysis https://genomics.ut.ee/en/tools/mr-mega Reedik Mägi, Momoko Horikoshi, Tamar Sofer, Anubha Mahajan, Hidetoshi Kitajima, Nora Franceschini, Mark I. McCarthy, COGENT-Kidney Consortium, T2D-GENES Consortium, Andrew P. Morris, Trans-ethnic meta-regression...
We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and ...